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Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
Castellani, Rudy; Moreira, Paula; Liu, Gang; Dobson, Jon; Perry, George; Smith, Mark; Zhu, XiongweiAbstract Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson’s disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in par...
Redox metals and oxidative abnormalities in human prion diseases
Petersen, Robert; Siedlak, Sandra; Lee, Hyoung-Gon; Kim, Yong-Sun; Nunomura, Akihiko; Tagliavini, Fabrizio; Ghetti, Bernardino; Cras, PatrickPrion diseases are characterized by the accumulation of diffuse and aggregated plaques of protease-resistant prion protein (PrP) in the brains of affected individuals and animals. Whereas prion diseases in animals appear to be almost exclusively transmitted by infection, human prion diseases most often occur sporadically and, to a lesser extent, by inheritance or infection. In the sporadic cases (sporadic Creut...
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