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The maximal electroshock seizure (MES) model in the preclinical assessment of p...
Castel-Branco, M. M.; Alves, G. L.; Figueiredo, I. V.; Falcão, A. C.; Caramona, M. M.The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...
The maximal electroshock seizure (MES) model in the preclinical assessment of p...
Castel-Branco, M. M.; Alves, G. L.; Figueiredo, I. V.; Falcão, Amílcar; Caramona, M. M.The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...
Lamotrigine analysis in blood and brain by high-performance liquid chromatography
Castel-Branco, M. M.; Almeida, A. M.; Falcão, A. C.; Macedo, T. A.; Caramona, M. M.; Lopez, F. G.A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...
Lamotrigine analysis in blood and brain by high-performance liquid chromatography
Castel-Branco, M. M.; Almeida, A. M.; Falcão, Amílcar; Macedo, T. A.; Caramona, M. M.; Lopez, F. G.A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...
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