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From antimicrobial to anticancer peptides. a review
Gaspar, Diana; Veiga, A. Salomé; Castanho, Miguel A. R. B.Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Although AMPs have been essentially studied and developed as potential alternatives for fighting infectious diseases, their use as anticancer peptides (ACPs) in cancer therapy either alone or in combination with other conventional drugs has been regarded as a therapeutic strategy to explore. As human cancer remains ...
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
Vigant, Frederic; Lee, Jihye; Hollmann, Axel; Tanner, Lukas B.; Ataman, Zeynep Akyol; Yun, Tatyana; Shui, Guanghou; Aguilar, Hector C.; Zhang, Dong© 2013 Vigant et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 mM), and was...
Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-memb...
Hollmann, Axel; Matos, Pedro M.; Augusto, Marcelo T.; Castanho, Miguel A. R. B.; Santos, Nuno C.© 2013 Hollmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; Recently, the covalent binding of a cholesterol moiety to a classical HIV-1 fusion inhibitor peptide, C34, was shown to potentiate its antiviral activit...
Intracellular nucleic acid delivery by the supercharged dengue virus capsid pro...
Freire, João Miguel; Veiga, Ana Salomé; Conceição, Thaís M.; Kowalczyk, Wioleta; Mohana-Borges, Ronaldo; Andreu, David; Santos, Nuno C.© 2013 Freire et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian ce...
Neuropeptide kyotorphin (tyrosyl-arginine) has decreased levels in the cerebro-...
Santos, Sara Matos; Garcia-Nimo, Laura; Sá Santos, Sónia; Tavares, Isaura; Cocho, José A.; Castanho, Miguel A. R. B.In Alzheimer’s disease (AD), besides the characteristic deterioration of memory, studies also point to a higher pain tolerance in spite of sensibility preservation. A change in the normal tau protein phosphorylation is also characteristic of AD, which contributes to the pathogenesis of the disease and is useful in early diagnosis. Kyotorphin (KTP) is an endoge-nous analgesic dipeptide (Tyr-Arg) for which there ...
Translocating the blood-brain barrier using electrostatics
Ribeiro, Marta M. B.; Domingues, Marco M.; Freire, João M.; Santos, Nuno C.; Castanho, Miguel A. R. B.Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. ; Mammalian cell membranes regulate homeostas...
The mechanism of action of antimicrobial peptides: lipid vesicles vs. bacteria
Melo, Manuel N.; Castanho, Miguel A. R. B.Copyright © 2012 Melo and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium...
Carvalho, Filomena A.; Carneiro, Fabiana A.; Martins, Ivo C.; Assunção-Miranda, Iranaia; Faustino, André F.; Pereira, Renata M.; Bozza, Patricia T.Copyright © 2012, American Society for Microbiology. All Rights Reserved. ; Dengue virus (DENV) affects millions of people, causing more than 20,000 deaths annually. No effective treatment for the disease caused by DENV infection is currently available, partially due to the lack of knowledge on the basic aspects of the viral life cycle, including the molecular basis of the interaction between viral components ...
Using zeta-potential measurements to quantify peptide partition to lipid membranes
Freire, João M.; Domingues, Marco M.; Matos, Joana; Melo, Manuel N.; Veiga, Ana Salomé; Santos, Nuno C.; Castanho, Miguel A. R. B.© The Author(s) 2011. This article is published with open access at Springerlink.com. ; Open Access: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. ; Many cellular phenomena occur on the biomembranes. There are plenty...
Quantifying molecular partition of charged molecules by Zeta-potential measurem...
Freire, João Miguel; Domingues, Marco M.; Matos, Joana; Melo, Manuel N.; Veiga, Ana Salomé; Santos, Nuno C.; Castanho, Miguel A. R. B.Copyright ©2010 The European Peptide Society
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