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Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Tr...
Maia, Alexandra S.; Ribeiro, Ana R.; Amorim, Catarina L.; Barreiro, Juliana C.; Cass, Quezia B.; Castro, Paula M.L.; Tiritan, Maria E.Antibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were follow...
Fases estacionárias quirais para cromatografia líquida de alta eficiência
Lourenço,Tiago de Campos; Cassiano,Neila Maria; Cass,Quezia B.The development of Chiral Stationary Phases (CSPs) for high performance liquid chromatography has been studied by various researches around the world, especially, since 1980. This simple interest has been transformed into a tool of great technological value for the industrial community and scholars in general providing the existence of several CSPs, which act through different mechanisms of chiral discriminatio...
Structural insights into the molecular basis responsible for the effects of imm...
Guido,Rafael V. C.; Cardoso,Carmen L.; Moraes,Marcela C. de; Andricopulo,Adriano D.; Cass,Quezia B.; Oliva,GlauciusThe development of fast and reliable methods for the identification of new bioactive compounds is of utmost importance to boost the process of drug discovery and development. Immobilized enzyme reactors (IMERs), integrated with high performance liquid chromatography (HPLC), are attractive and versatile tools for screening collections consisting of natural products and synthetic small molecules. Standard kinetic...
Imobilização de enzimas em suportes cromatográficos: uma ferramenta na busca po...
Cardoso,Carmen Lúcia; Moraes,Marcela C. de; Cass,Quezia B.The development and characterization of bioreactors or IMER (immobilized enzyme reactors) as research tools are important in the scope of medicinal chemistry and constitute an alternative for the rational development of drugs. This approach does not require highly purified enzymes or a great amount of protein, but increase the enzymatic stability against heat, organic solvents and pH, without too much loss of c...
Development of a HPLC method to follow the degradation of phenol by electrochem...
Andrade,Leonardo S.; Laurindo,Edison A.; Oliveira,Regina V. de; Rocha-Filho,Romeu C.; Cass,Quezia B.The development and validation of a HPLC method to follow the degradation of phenol by electrochemical or photoelectrochemical treatment are described. This method, which allows determining amounts of phenol, p-benzoquinone and cathecol in electrolyzed or photoelectrolyzed solutions, was used for analysis of reaction intermediates during electrooxidation or photoelectrooxidation of phenol using a Ti-Pt/PbO2 (ob...
Discriminação quiral por CLAE em carbamatos de polissacarídeos: desenvolvimento...
Cass,Quezia B.; Tiritan,M. Elizabeth; Bassi,Ana Lúcia; Calafatti,Silvana A.; Degani,Ana Luiza G.The importance of chromatographic separation of enantiomers has been acknowledged. This review surveys the development, application and perspectives of polysaccharide carbamates as chiral stationary phase for HPLC.
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