Encontrados 4 documentos, a visualizar página 1 de 1
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal ca...
Carvalho, Agostinho; Giovannini, Gloria; De Luca, Antonella; D’Angelo, Carmen; Casagrande, Andrea; Iannitti, Rossana G.; Ricci, GiovanniWe thank Dr. Cristina Massi Benedetti for digital art and editing ; Recognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastroin...
Host defense pathways against fungi : the basis for vaccines and immunotherapy
Carvalho, Agostinho; Cunha, Cristina; Iannitti, Andrea; Casagrande, Andrea; Bistoni, Francesco; Aversa, Franco; Romani, LuiginaFungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understand...
CD4+ T cell vaccination overcomes defective cross-presentation of fungal antige...
Luca, Antonella De; Iannitti, Rossana G.; Bozza, Silvia; Beau, Remi; Casagrande, Andrea; D’Angelo, Carmen; Moretti, Silvia; Cunha, CristinaAspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4+ and CD8+ T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leadi...
Immunogenetic profiling to predict risk of invasive fungal diseases : where are...
Cunha, Cristina; Aversa, Franco; Bistoni, Giovanni; Casagrande, Andrea; Rodrigues, Fernando José dos Santos; Romani, Luigina; Carvalho, AgostinhoInvasive fungal diseases remain nowadays life-threatening conditions affecting multiple clinical settings. The onset of these diseases is dependent on numerous factors, of which the "immunocompromised" phenotype of the patients is the more often acknowledged. However, and despite comparable immune dysfunction, not all patients are ultimately susceptible to disease, suggesting that additional risk factors, likel...
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