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Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as The...
Cardoso, Susana; Santos, Renato; Correia, Sonia; Carvalho, Cristina; Zhu, Xiongwei; Lee, Hyoung-Gon; Casadesu, Gemma; Smith, Mark A.; Perry, GeorgeInsulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular metabolism ar...
Data: 2009
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Origem: Estudo Geral - Universidade de Coimbra
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