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The rs5743836 polymorphism in TLR9 confers a population-based increased risk of...
Carvalho, Agostinho; Cunha, Cristina; Almeida, A. J.; Osório, Nuno S.; Saraiva, Margarida; Coelho, Maria Teixeira; Pedreiro, Susana; Torrado, EgídioWe are grateful to Paulo Vieira, Cecília Leão, Manuel T. Silva, Nuno Sousa, Jorge Correia- Pinto, Joana Palha, Margarida Correia-Neves, Margarida Lima and Matthew Berry for all their input throughout these studies and critical reading of the manuscript. We are grateful to the patients who joint this study as well as to all members of the Life and Health Sciences Research Institute and School of Health Sciences,...
Detection of the Epstein-Barr virus in blood and bone marrow mononuclear cells ...
Marques, Herlander; Catarino, Raquel; Domingues, Nelson; Barros, Eliane; Portela, Catarina; Almeida, Maria Inês; Costa, Sandra; Reis, R. M.The Epstein-Barr virus (EBV) is associated with a large spectrum of lymphoproliferative diseases. Traditional methods of EBV detection include the immunohistochemical identification of viral proteins and DNA probes to the viral genome in tumoral tissue. The present study explored the detection of the EBV genome, using the BALF5 gene, in the bone marrow or blood mononuclear cells of patients with diffuse large B...
Genetics and molecular epidemiology of multiple myeloma : the rationale for the...
Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Reis, R. M.; García-Sanz, Ramón; Jurado, Manuel; Ríos, RafaelThere is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main fi...
Economic analysis of rituximab in combination with cyclophosphamide, vincristin...
Braga, Paula; Carvalho, Susana; Gomes, Marília; Guerra, Lurdes; Lúcio, Paulo; Marques, Herlander; Negreiro, Filipa; Pereira, Catarina; Silva, CatarinaEvaluate costs and benefits of rituximab in combination with cyclophosphamide/vincristine/prednisolone chemotherapy regimen (R-CVP), in previously untreated patients with indolent non-Hodgkin lymphoma (NHL), compared to CVP alone from a Portuguese National Health System (NHS) perspective.Cost-effectiveness (Life Years Gained--LYG) and cost-utility analysis (Quality Adjusted Life Years--QALYs) were performed for...
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