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Structural and conformational effects of metal binding to the S100B cytokine

Tese de mestrado em Bioquímica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2011 ; S100B is a Ca2+, Cu2+ and Zn2+-binding protein highly expressed in human brain, with a intra and extracellular function. It is involved in several pathological processes in which metal homeostasis is imbalanced, such as AD and ALS, which account for a modified protein function. Metal binding to S100B ...