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Insights into the Synthesis of Steroidal A-Ring Olefins
Varela, Carla M.; Roleira, Fernanda M. F.; Costa, Saul C. P.; Tinto, Alexandra S. C. T.; Martins, Ana I. O. S.; Carvalho, Rui A.; Teixeira, Natércia A.one (5), from the D1-3-keto enone, (5a,17b)-3-oxo-5-androst-1-en-17-yl acetate (1), through a strategy involving the reaction of D1-3-hydroxy allylic alcohol, 3b-hydroxy-5a-androst-1-en-17b-yl acetate (2), with SOCl2 , was revisited in order to prepare and biologically evaluate 5 as aromatase inhibitor for breast cancer treatment. Surprisingly, the followed strategy also afforded the isomeric D2-olefin 6 as a b...
Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to...
Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J.Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitoch...
Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Mai...
Sandro, L. Pereira; Grãos, Mário; Rodrigues, Ana Sofia; Anjo, Sandra I.; Carvalho, Rui A.; Oliveira, Paulo J.; Arenas, Ernest; Ramalho-Santos, JoãoThe mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we sought to understand the effect of mitochondrial complex III inhibition during neuronal differentiation of mouse embryonic stem cells. When exposed to antimycin A, a specific complex III inhibitor, embryonic stem cells failed to differentiate into dopaminer...
Ruído na cidade do Porto - A evolução em duas décadas
Antonio P. O. Carvalho; Rui A. F. JesusToday’s Oporto’s urban environment presents significative differences at social, infrastructure, activities and transport matters from 20 years ago. This work characterizes the noise evolution from 1990 to 2011 using in situ measurements. ; Em 1990, um jornal diário afirmava que o Porto era a cidade de todos os ruídos. Agora, 21 anos depois, o ambiente urbano portuense apresenta diferenças tanto so...
Ocular injectable formulation assessment for oxidized dextran-based hydrogels
Maia, João; Ribeiro, Maximiano P.; Ventura, Carla; Carvalho, Rui A.; Correia, Ilídio J.; Gil, Maria H.Initiator-free injectable hydrogels are very interesting for drug and/or cell delivery applications, since they can be administered in a minimally invasive way, and avoid the use of potentially harmful chemical initiators. In the current work, oxidized dextran crosslinked with adipic acid dihydrazide hydrogels were further characterized and tuned to produce formulations, with the aim of producing an injectable ...
Conformational Studies of Poly(9,9-dialkylfluorene)s in Solution Using NMR Spec...
Justino, Licínia L. G.; Ramos, M. Luísa; Abreu, Paulo E.; Carvalho, Rui A.; Sobral, Abilio J. F. N.; Scherf, Ullrich; Burrows, Hugh D.Relationships have been obtained between intermonomer torsional angle and NMR chemical shifts (1H and 13C) for isolated chains of two of the most important poly(9,9-dialkylfluorenes), poly[9,9-bis(2-ethylhexyl)fluorene-2,7-diyl] (PF2/6) and the copolymer poly(9,9-dioctylfluorene-co-[2,1,3]benzothiadiazole-4,7-diyl) (F8BT), using DFT calculations. The correlations provide a model for NMR spectral data interpreta...
H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7...
André, João P.; Brücher, Ernö; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.The ligand H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) is a H4dota-like macrocyclic ligand with a carboxymethyl CH2COOH substituent at the C(alpha) atom of one of the four acetate pendant arms of H4dota (=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), present as a racemic mixture of (alphaR) and (alphaS) enantiomers. The protonation constants ...
Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric a...
Ribeiro, Laura; Carvalho, Rui A.; Ferreira, Domingos C.; Veiga, Francisco J. B.This work deals with multicomponent complex formation of vinpocetine (VP) with [beta]-cyclodextrin ([beta]CD), sulfobutyl ether [beta]-cyclodextrin (SBE[beta]CD) and tartaric acid (TA), in the presence or absence of water-soluble polymers, in aqueous solution. Complexation was monitored by phase-solubility and proton nuclear magnetic resonance (1H NMR) studies. TA demonstrated a synergistic effect on VP solubil...
DOTASA, an Asymmetrical Derivative of DOTA Substituted at one Acetate pendant A...
André, João P.; Brücher, Ernö; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.The ligand H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) is a H4dota-like macrocyclic ligand with a carboxymethyl CH2COOH substituent moiety at the C(alpha) atom of one of the four acetate pendant arms of H4dota (=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), present as a racemic mixture of (alphaR) and (alphaS) enantiomers. The protonation con...
DOTASA revisited : 1H NMR and potentiometric studies of a highly asymmetrical l...
André, João P.; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.; Brücher, ErnöPoster apresentado no 8th FIGIPAS Meeting in Inorganic Chemistry, Atenas, Grécia, 6 - 9 Jul. 2005. ; DOTASA (1,4,7,10-tetraazacyclodo-decane-1-(R,S)-succinic acid-4,7,10-triacetic acid) is a DOTA-like macrocyclic ligand showing a carboxymethyl -CH2COOH substituent moiety at a C carbon of one of the four acetate pendant arms, present as a racemic mixture of R and S configurations.The protonation constants of t...
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