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BDNF regulates the expression and traffic of NMDA receptors in cultured hippoca...
Caldeira, Margarida V.; Melo, Carlos V.; Pereira, Daniela B.; Carvalho, Ricardo F.; Carvalho, Ana Luísa; Duarte, Carlos B.The neurotrophin BDNF regulates the activity-dependent modifications of synaptic strength in the CNS. Physiological and biochemical evidences implicate the NMDA glutamate receptor as one of the targets for BDNF modulation. In the present study, we investigated the effect of BDNF on the expression and plasma membrane abundance of NMDA receptor subunits in cultured hippocampal neurons. Acute stimulation of hippoc...
Data: 2007
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Origem: Estudo Geral - Universidade de Coimbra
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