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New steroidal 17b-carboxy derivatives present anti-5a-reductase activity and an...

Amaral, Cristina; Varela, Carla; Correia-da-Silva, Georgina; da Silva, Elisário Tavares; Carvalho, R. A.; Costa, Saul C. P.; Cunha, Sara C.

The androgens testosterone (T) and dihydrotestosterone (DHT), besides playing an important role in prostate development and growth, are also responsible for the development and progression of benign prostate hyperplasia (BPH) and prostate cancer. Therefore, the actions of these hormones can be antagonized by preventing the irreversible conversion of T into DHT by inhibiting 5a-reductase (5a-R). This has been a ...



1H NMR Spectroscopic and Quantum Chemical Studies on a Poly(ester amide) Model ...

Fonseca, A. C.; Jarmelo, S.; Carvalho, R. A.; Fausto, R.; Gil, M. H.; Simões, P. N.

The molecular structure of the l-arginine derivative, Nα-benzoyl-l-argininate ethyl ester chloride (BAEEH+·Cl−), was characterized by combining quantum chemical methods and 1H NMR spectroscopy. A conformational search on the potential energy surfaces of the three lowest-energy tautomers of BAEEH+ [A: R−N+H═(NH2)2; B: R−NH−C(═NH)N+H3; C: R−N+H2−C(═NH)NH2; R = C6H5C(═O)NH−CH(COOCH2CH3)CH2CH2CH2−] was carried out ...


New insight into the discrimination between omeprazole enantiomers by cyclodext...

Figueiras, A.; Sarraguça, J. M. G.; Pais, A. A. C. C.; Veiga, J. F.; Carvalho, R. A.

We report results regarding the use of 1H-NMR spectroscopy in the study of the conformational behaviour and optical activity of omeprazole. Changes in the chemical shifts of chosen atoms reveal that the conformational behaviour of omeprazole is temperature and pH sensitive. Separation and identification of omeprazole enantiomers in the presence of natural and derivative cyclodextrins, such as ß-cyclodextrin (ßC...


Recuperação e concentração dos componentes do aroma do abacaxi por pervaporação.

CABRAL, L. M. C.; CARVALHO, R. A.; PALÁCIO, D. N. M.; MONTEIRO, F. S.; BIZZO, H. R.; MATTA, V. M.

2006

Data: 2006   |   Origem: OASIS br

Properties of chemically modified gelatin films

Carvalho,R. A. de; Grosso,C. R. F.

Edible and/or biodegradable films usually have limited water vapor barriers, making it difficult to use them. Thus, the objective of this work was to evaluate the effect of a chemical reticulation treatment with formaldehyde and glyoxal on the mechanical properties, water vapor permeability, solubility and color parameters of gelatin-based films. Formaldehyde and glyoxal were added to the filmogenic solution in...

Data: 2006   |   Origem: OASIS br

Recovery of hippocampal metabolism from hypoxia - role of the adenosine A1 rece...

Duarte, J. M.; Cunha, R. A.; Carvalho, R. A.

Título do suplemento: Book of Abstracts ESMRMB 2005 22nd Annual Scientific Meeting Basle/CH, Sept. 15-18, 2005


X-ray Diffraction and 1H NMR in Solution: Structural Determination of Lanthani...

Valencia, L.; Martinez, J.; Macías, A.; Bastida, R.; Carvalho, R. A.; Geraldes, C. F. G. C.

Complexes between the Py2N6Ac4 (H4L) ligand containing four carboxylate pendant arms and trivalent lanthanide ions have been synthesized, and structural studies have been made both in the solid state and aqueous solution. The crystal structures of the La, Ce, Sm, Tb, Dy, Ho, Er, Tm, and Lu complexes, with chemical formulas [LaH2L](NO3)·3H2O (1), [Ce4L2](NO3)4·30H2O (2), [SmHL]·EtOH·3H2O (5), [TbHL]·EtOH·3H2O (8...


Ocorrência de Giardia spp. em bezerros leiteiros no Brasil

Guimarães,A.M.; Guedes,E.; Carvalho,R.A.

Fecal samples were collected from 50 female Holstein calves (1-90 days old) from a commercial dairy cattle farm located in Lavras, Minas Gerais, Brazil and examined for presence of Giardia cysts using the zinc sulfate flotation method. A total of 120 samples were collected from March 1999 to April 2000, and fecal consistency (normal or diarrheic) was noted prior to the examination for Giardia cysts. Giardia spp...

Data: 2001   |   Origem: OASIS br

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia