Encontrados 8 documentos, a visualizar página 1 de 1
Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones...
Lopes, Luciane C.; Carvalho, João E.; Kakimore, Marise; Vendramini-Costa, Débora B.; Medeiros, Maria Augusta; Spindola, Humberto M.; Ávila-Román, J.Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses high levels of COX-2, suggesting its role in inflammatory process, and also a link between chronic inflammation and cancer-associated process. Dichloromethane cr...
Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3...
Savariz,Franciele C.; Formagio,Anelise S. N.; Barbosa,Valéria A.; Foglio,Mary Ann; Carvalho,João E. de; Duarte,Marta C. T.; Dias Filho,Benedito P.With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activit...
Furanoditerpenes from Pterodon pubescens benth with selective in vitro anticanc...
Spindola,Humberto M.; Carvalho,João E. de; Ruiz,Ana Lúcia T. G.; Rodrigues,Rodney A. F.; Denny,Carina; Sousa,Ilza M. de Oliveira; Tamashiro,Jorge Y.Activity guided fractionation of Pterodon pubescens Benth. methylene chloride-soluble fraction afforded novel 6α-acetoxi 7β-hydroxy-vouacapan 1 and four known diterpene furans 2, 3, 4, 5. The compounds were evaluated for in vitro cytotoxic activities against human normal cells and tumour cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung, non-small cells), OVCAR-03 (ovarian), PC-3 (prostate...
Do gene à função: investigação do papel dos receptores de glutamato na fisiolog...
Carvalho, João E.Relatório de projecto no âmbito de Bolsa Universidade de Lisboa/Fundação Amadeu Dias (2008/2009)
Effect of Artemisia annua L. leaves essential oil and ethanol extract on behavi...
Perazzo,Fabio F.; Lima,Leonardo M.; Maistro,Edson Luis; Carvalho,João E.; Rehder,Vera L. G.; Carvalho,José C. T.Artemisia annua has been used as a traditional plant for the treatment of malaria and fever in China because of the presence of its active compound, artemisinin. The present study evaluated the central activity of the essential oil and the crude ethanol extract of A. annua L. in animals as a part of a psychopharmacological screening of this plant. The extract was prepared in ethanol (AEE) and the essential oil ...
Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides
Ruiz,Ana Lúcia T. G.; Taffarello,Denise; Souza,Vanessa H. S.; Carvalho,João E.Um grande número de espécies com uso medicinal tradicional ainda continua sem comprovação da eficácia e da segurança de seu uso. Este artigo apresenta uma pequena revisão sobre os trabalhos publicados com boldo (Peumus boldus) e carqueja (Baccharis genistelloides). Os estudos farmacológicos realizados com P. boldus e B. genistelloides comprovam várias das atividades atribuídas popularmente a esses chás, além de...
Synthesis and antiproliferative activity of novel limonene derivatives with a s...
Figueiredo,Isis M.; Santos,Luciane V. dos; Costa,Willian F. da; Carvalho,João E. de; Silva,Cleuza C. da; Sacoman,Juliana L.; Kohn,Luciana K.A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12...
Sleep habits and starting time to school in Brazilian children
Silva,Tatiana A.; Carvalho,Luciane B.C.; Silva,Luciana; Medeiros,Marilaine; Natale,Vivian B.; Carvalho,Joao E.C.; Prado,Lucila B.F.; Prado,Gilmar F.OBJECTIVE: This study investigated the sleep habits in Brazilian children according to age, gender and starting time to school. METHOD: We investigated 2,482 scholars aged 7 to 10 years. We compared sleep habits, gender, and starting time to school (morning and afternoon). RESULTS: Sixty-one per cent of the children presented sleep rituals before sleep. Milk drinking before sleep was more frequent among seven y...
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