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Ethical, technical and legal procedures of the medical doctor responsibility to...

The forensic toxicology (TF) is a science of analytical basis, aiming to clarify legal issues related to poisoning, whether or not fatal, within the various areas of law (criminal, civil, labor, etc.). The analysis that are more often requested (with a tendency to increase and gaining rising attention) are those concerning the procedures involving supervision of driving under the influence of alcohol and psycho...

Cross-Functioning between the Extraneuronal Monoamine Transporter and Multidrug...

Isolated heart cells are highly susceptible to the toxicity of catecholamine oxidation products, namely, to catecholamine-glutathione adducts. Although cellular uptake and/or efflux of these products may constitute a crucial step, the knowledge about the involvement of transporters is still very scarce. This work aimed to contribute to the characterization of membrane transport mechanisms, namely, extraneuronal...

O processo de projeto de uma edificação mais sustentável : contribuições relati...

In spite of recent efforts of the academic community and the increasing interest of sector entities to spread concepts and practices of more sustainable buildings, the adoption of sustainable requirements in the project process is not systematic in most part of project firms. The lack of pilot project has been point out as major reason for the existence of a large gap between what is available and the practices...

Reactivity of paraquat with sodium salicylate: Formation of stable complexes

Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the antithrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to ...

Time dependent activation of transcription factors in freshly isolated cardiomy...

http://www.sciencedirect.com/science/article/B6TCR-4PKH640-H/1/d0195093d7c07e99f21ac2b29efae75f

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formati...

High concentrations of circulating biogenic catecholamines often exist during the course of several cardiovascular disorders. Additionally, coronary dysfunctions are prominent and frequently related to the ischemic and reperfusion phenomenon (I/R) in the heart, which leads to the release of large amounts of catecholamines, namely adrenaline, and to a sustained generation of reactive oxygen species (ROS). Thus, ...

Evaluation of toxic/protective effects of the essential oil of Salvia officinal...

Prova tipográfica (In Press) ; For this study the essential oil (EO) of sage (Salvia officinalis L.) was isolated from air-dried vegetative aerial parts of the plants by hydrodistillation and analysed by GC and GC-MS. A total yield of 12.07 mg of EO per g of plant dry mass was obtained and more than 50 compounds identified. The major compounds were cis-thujone (17.4 %), alpha-humulene (13.3 %), 1,8-cineole (12...

Paraquat intoxication and hemocarboperfusion.

In the northeast of Portugal, paraquat intoxication is common. We report 31 patients, admitted at our institution from April 1997 to June 2004, with suspected paraquat intoxication. Thirty cases had suicidal intention and all have ingested the toxic by mouth. Treatment consisted of skin and digestive decontamination with gastric washing and activated charcoal or Fuller's Earth. The first medical care was perfor...

Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-bu...

2-Styrylchromones are a novel class of chromones, vinylogues of flavones (2-phenylchromones), which have recently been found in nature. The best described property of almost every group of flavones and other flavonoids, especially the hydroxylated derivatives, is their capacity to act as antioxidants. Indeed there is a widely accepted view that the positive health effects of flavones are due to their antioxidan...

Hepatoprotective activity of 2-styrylchromone derivatives against the pro-oxida...