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Adaptation to different salinities exposes functional specialization in the int...
Gregório, SÃlvia F.; Carvalho, Edison Samir Mascarelhas; Encarnação, Sandra; Wilson, J.; Power, Deborah; Canario, Adelino V. M.; Fuentes, J.The processing of intestinal fluid, in addition to a high drinking rate, is essential for osmoregulation in marine fish. This study analyzed the long-term response of the sea bream (Sparus aurata L.) to relevant changes of external salinity (12, 35 and 55ï€ p.p.t.), focusing on the anterior intestine and in the less-often studied rectum. Intestinal water absorption, epithelial HCO3– secretion and gene express...
Mucosal delivery of liposome-chitosan nanoparticles complexes
Carvalho, Edison Samir Mascarelhas; Grenha, Ana; Remuñán-López, Carmen; Alonso, Maria José; Seijo, BegoñaDesigning adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been refer...
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