Encontrados 5 documentos, a visualizar página 1 de 1
High glucose induces caspase-independent cell death in retinal neural cells
Santiago, A. R.; Cristóvão, A. J.; Santos, P. F.; Carvalho, C. M.; Ambrósio, A. F.Diabetic retinopathy is a leading cause of blindness among adults in the western countries. It has been reported that neurodegeneration may occur in diabetic retinas, but the mechanisms underlying retinal cell death are poorly understood. We found that high glucose increased the number of cells with condensed nuclei and the number of TUNEL-positive cells, and caused an increase in the translocation of phosphati...
Changes in calcium dynamics following the reversal of the sodium-calcium exchan...
Araújo, I. M.; Carreira, B. P.; Pereira, T.; Santos, P. F.; Soulet, D.; Inácio, A.; Bahr, B. A.; Carvalho, A. P.; Carvalho, C. M.Proteolytic cleavage of the Na(+)/Ca(2+) exchanger (NCX) by calpains impairs calcium homeostasis, leading to a delayed calcium overload and excitotoxic cell death. However, it is not known whether reversal of the exchanger contributes to activate calpains and trigger neuronal death. We investigated the role of the reversal of the NCX in Ca(2+) dynamics, calpain activation and cell viability, in alpha-amino-3-hy...
HTLV-I associated tropical spastic paraparesis: cerebral spinal fluid evolutive...
Moreno-Carvalho,O.A.; Nascimento-Carvalho,C.M.C.; Galvão-Castro,B.In order to evaluate if there is variation on the intensity of cerebral spinal fluid (CSF) response during HTLV-I associated tropical spastic paraparesis (TSP) evolution we retrospectively reviewed 128 cases.The results indicate that although CSF inflammatory alterations can persist over a 10-year period.they tend to become slight or even absent after the second year of TSP evolution.
Tratamento térmico do leite acondicionado em filme plástico em banho-maria
Oliveira,AJ.de; Gallo,C.R.; Carvalho,C.M.deO presente trabalho foi realizado com a finalidade de se conseguir um procedimento de pasteurização prático e de baixo custo para pequenos produtores de leite, assegurando assim um aumento do tempo de conservação e consequentemente de comercialização do produto, sem riscos para o consumidor. Para tal, amostras de leite já acondicionadas em filme plástico (l litro) foram submetidas a diferentes tratamentos térmi...
Modulation of dopamine and noradrenaline release and of intracellular Ca2+ conc...
Malva, J. O.; Carvalho, A. P.; Carvalho, C. M.1. We studied the release of [3H]-dopamine and [3H]-noradrenaline (NA) from hippocampal synaptosomes induced by glutamate receptors and the associated Ca2+ influx through Ca2+ channels. The release of tritiated neurotransmitters was studied by use of superfusion system and the intracellular free Ca2+ concentration ([Ca2+]i) was determined by a fluorimetric assay with Indo-1 as a probe for Ca2+. 2. Presynaptic g...
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