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N-acetylcysteine and vancomycin alone and in combination against staphylococci ...
Leite, Bruna; Gomes, Fernando; Melo, P.; Souza, Clovis; Teixeira, P.; Oliveira, Rosário; Pizzolitto, ElisabethIntroduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives a...
Staphylococcus epidermidis biofilms control by N-acetylcysteine and rifampicin
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Pizzolitto, Elisabeth; Oliveira, RosárioMedical device-associated infections caused by Staphylococcus epidermidis usually involve biofilm formation and its eradication is particularly challenging. Although rifampicin has been proving to be one of the most effective antibiotics against S. epidermidis biofilms, its use as a single agent can lead to the acquisition of resistance. Therefore, we assessed the combined effect of rifampicin with N-acetylcyst...
Farnesol in combination with N-acetylcysteine against staphylococcus epidermidi...
Gomes, F. I.; Leite, Bruna; Teixeira, P.; Azeredo, Joana; Oliveira, RosárioStaphylococcus epidermidis is the most frequent cause of nosocomial sepsis and catheter-related infections, in which biofilm formation is considered to be the main virulence mechanism. In biofilm environment, microbes exhibit enhanced resistance to antimicrobial agents. This fact boosted the search of possible alternatives to antibiotics. Farnesol and N-acetylcysteine (NAC) are non-antibiotic drugs that have de...
Immune and inflammatory responses to Leishmania amazonensis isolated from diffe...
Souza,Valderes L de; Veras,Patrícia ST; Welby-Borges,Marcus; Silva,Tânia MC; Leite,Bruna R; Ferraro,Rodrigo B; Meyer-Fernandes,José R; Barral,AldinaLeishmania amazonensis causes different diseases depending on the host and parasitic virulence factors. In this study, CBA mice were infected with L. amazonensis isolates from patients with localized (Ba125), diffuse cutaneous (Ba276) or visceral leishmaniasis (Ba109). Mice infected with Ba125 and Ba276 progressed rapidly and lesions displayed an infiltrate rich in parasitized macrophages and were necrotic and ...
In vitro activity of daptomycin, linezolid and rifampicin on Staphylococcus epi...
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Oliveira, Rosário; Pizzolitto, ElisabethOwing to their massive use, Staphylococcus epidermidis has recently developed significant resistance to several antibiotics, and became one of the leading causes of hospital-acquired infections. Current antibiotics are typically ineffective in the eradication of bacteria in biofilmassociated persistent infections. Accordingly, the paucity of effective treatment against cells in this mode of growth is a key fact...
Strategies to control Staphylococcus epidermidis biofilms
Gomes, F. I.; Leite, Bruna; Teixeira, P.; Oliveira, RosárioStaphylococcus epidermidis is the staphylococci species most commonly associated with bacteremia and hospital-acquired infections and has recently arisen as the leading cause of infections related to indwelling medical devices such as vascular catheters, prosthetic joints and artificial heart valves. The prevalence of S. epidermidis in hospital-acquired infections is due to its ability to adhere and form biofil...
Família e redes sociais de apoio para o atendimento das demandas de saúde do idoso
Mota,Fernanda Rochelly do Nascimento; Oliveira,Edmara Teixeira; Marques,Marilia Braga; Bessa,Maria Eliana Peixoto; Leite,Bruna Michelle BelémA proposta foi avaliar as redes sociais de apoio das famílias com idosos segundo o modelo Calgary de avaliação de família (MCAF). Estudo quantitativo do tipo transversal de caráter exploratório e descritivo, desenvolvido juntos às famílias com idosos residentes em bairros periféricos de Fortaleza-CE, de novembro/2008 a janeiro/2009. Dados obtidos de 218 famílias através de entrevista em domicílio ao responsável...
Response of Staphylococcus epidermidis biofilms cells to the effect of farnesol
Leite, Bruna; Gomes, F.I.; Teixeira, P.; Pizzolitto, Elisabeth; Oliveira, RosárioObjective:Staphylococcus epidermidis is a leading cause of medical-device-related infections, especially in immunocompromised patients. The treatment of these infections is further complicated by the emergence of multiresistant strains. The ability of S. epidermidis to form biofilms on biotic and abiotic surfaces is believed to contribute significantly to the pathogenesis of these infections. Biofilms are notor...
Effect of N-Acetylcysteine alone and in combination with rifampicin on Staphylo...
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Pizzolitto, Elisabeth; Oliveira, RosárioMedical device-associated infections caused by pathogens such as Staphylococcus epidermidis might involve biofilm formation and those are particularly challenging. The involvement of antibiotic resistant Staphylococci, exacerbates the problem. Rifampicin cannot be used as a single agent to treat infections because of the rapid selection of resistant mutants. However, combinations of rifampicin with other anti-s...
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