Encontrados 43 documentos, a visualizar página 1 de 5
In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...
Martinho, Olga; Oliveira, Renato Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João TabordaTreatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...
Iodine Intake in Portuguese School Children
Limbert, Edward; Prazeres, Susana; São Pedro, Márcia; Madureira, Deolinda; Miranda, Ana; Ribeiro, Manuel; Carrilho, Francisco; Jácome de Castro, JObjective: The aim of the present study was to evaluate iodine intake in portuguese school children in order to inform health authorities of eventual measures to be implemented. Introduction: Iodine is the key element for thyroid hormone synthesis and its deficiency even mild, as found in other European countries, may have deleterious effects in pregnancy resulting in cognitive problems of offsprings. In Portug...
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...
Oliveira, Antônio Talvane Torres; Pinheiro, Céline; Filho, A. L.; Brito, Maria José; Martinho, Olga; Matos, Delcio; Carvalho, André LopesAntônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study ; Prova tipográfica (uncorrected proof) ; Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as ...
Impacto de um programa educativo para doentes após AVC e cuidadores informais n...
Damião, Liliete; Pereira, Carla; Baptista, Filomena; Alves, Anabela; Silva, Ana; Carvalho, André; Vera-Cruz, Carla; Pires, Filipa; Prates, LeonorComunicação apresentada no 6.º Congresso Português do AVC decorrido entre 2 e 4 de fevereiro de 2012, e publicada na revista Sinapse 12, 1.
Surgical-site infection risk in oncologic digestive surgery
Castro,Paulo de Tarso Oliveira e; Carvalho,André Lopes; Peres,Stela Verzinhasse; Foschini,Milene Mitsuyuki; Passos,Afonso Dinis CostaSurgical-site infection (SSI) is the most prevalent type of hospital infection in surgical patients and is associated with an increase in hospital stay, costs and morbidity/lethality. The knowledge of the main risk factors for this type of infection is important for the establishment of prevention measures regarding modifiable risks factors. The objective of the preset study was to assess the occurrence of SSI ...
Antidepressant drugs.
Aguiar, C Clayton; Castro, Thiago R; Carvalho, André F; Vale, Otoni C; Sousa, F Cléa; Vasconcelos, Silvânia MDepression is a disorder of mood that causes strong impact on the patient and his family's quality of life. The increasing number of cases and its social consequences have made depression a great public health problem. Some depressant patients develop suicide thoughts and may try suicide later. The disease occurs in all ages and its prevalence is of 7.4%. Women aged 15 to 29 are more likely to be affected, wher...
Estratégias de marketing das PME - diagnóstico e análise
Carvalho, André Vieira SilvaO objectivo do estudo foi identificar as estratégias de Marketing que as Pequenas e Médias Empresas (PME) portuguesas, e em particular as da região Centro, utilizam para se promoverem a elas próprias e aos seus produtos. Foram recolhidos 133 inquéritos através de um formulário online. Os dados foram depois tratados quer em análises descritivas quer em análises de variância multivariada (MANOVA) com recurso a te...
Extração automática de modelos de sistemas de tempo real
Carvalho, André Ribeiro deDissertação de mestrado em Engenharia de Informática ; Esta dissertação insere-se no contexto da investigação sobre verificação de programas de tempo-real. Tendo como principais referências o artigo de Alan Burns [10] e a dissertação de Joel Carvalho [16], introduz-se aqui uma ferramenta capaz de gerar automaticamente modelos Uppaal representativos de programas escritos em Ada. Através desses modelos, e com o ...
Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...
Oliveira, Antônio Talvane Torres; Reis, R. M.; Afonso, Julieta; Martinho, Olga; Matos, Delcio; Carvalho, André Lopes; Vazquez, Vinícius LimaThis study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD ass...
Validity of the Brazilian Portuguese version of the bipolar spectrum diagnostic...
Castelo,Milena S.; Carvalho,Eduardo R.; Gerhard,Emília S.; Macêdo,Danielle Silveira; Ferreira,Eduardo D.; Carvalho,André F.OBJECTIVE: Bipolar spectrum disorders (BSDs) are prevalent and frequently unrecognized and undertreated. This report describes the development and validation of the Brazilian version of the bipolar spectrum diagnostic scale (B-BSDS), a screening instrument for bipolar disorders, in an adult psychiatric population. METHOD: 114 consecutive patients attending an outpatient psychiatric clinic completed the B-BSDS. ...
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