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Head-to-head comparison of two online nomograms for prostate biopsy outcome pre...
Oliveira, M; Marques, V; Carvalho, AP; Santos, ALEVEL OF EVIDENCE: 2b. What's known on the subject? and What does the study add? In recent years, several nomograms were developed in an effort to decrease the number of unnecessary prostate biopsies. The European SWOP-PRI and the North American PCPT are among the most popular. However, evidence on the relative predictive accuracy is lacking. A head-to-head comparison on the diagnostic accuracy of two previousl...
Head-to-head comparison of two online nomograms for prostate biopsy outcome pre...
Oliveira, M; Marques, V; Carvalho, AP; Santos, ALEVEL OF EVIDENCE: 2b. What's known on the subject? and What does the study add? In recent years, several nomograms were developed in an effort to decrease the number of unnecessary prostate biopsies. The European SWOP-PRI and the North American PCPT are among the most popular. However, evidence on the relative predictive accuracy is lacking. A head-to-head comparison on the diagnostic accuracy of two previousl...
Tratamiento quirúrgico de duplicidad peneana completa
Carvalho, AP; Ramires, R; Soares, J; Carvalho, LF; Filinto, MPenile duplication is a rare anomaly with an incidence of 1 in 5,500,000. It is almost associated with other malformations like double bladder, presence of the cloaca, imperforate anus, duplication of the recto sigmoid and vertebral deformities. The authors present the surgical technique to resolve a rare case of complete penile duplication in a 4 years old child, without any other malformation.
Tratamiento quirúrgico de duplicidad peneana completa
Carvalho, AP; Ramires, R; Soares, J; Carvalho, LF; Filinto, MPenile duplication is a rare anomaly with an incidence of 1 in 5,500,000. It is almost associated with other malformations like double bladder, presence of the cloaca, imperforate anus, duplication of the recto sigmoid and vertebral deformities. The authors present the surgical technique to resolve a rare case of complete penile duplication in a 4 years old child, without any other malformation.
Contact sensitizer nickel sulfate activates the transcription factors NF-kB and...
Cruz, MT; Gonçalo, Margarida; Figueiredo, A; Carvalho, AP; Duarte, CBNuclear factor kappa B (NF-kB) and activating protein-1 (AP-1) transcription factors are ubiquitously expressed signaling molecules known to regulate the transcription of a large number of genes involved in immune responses, namely the inducible isoform of nitric oxide synthase (iNOS). In this study, we demonstrate that a fetal skin-derived dendritic cell line (FSDC) produces nitric oxide (NO) in response to th...
The sensitizer 2,4-dinitrofluorobenzene activates caspase-3 and induces cell de...
Cruz, MT; Duarte, CB; Gonçalo, Margarida; Figueiredo, A; Carvalho, AP; Lopes, MCIn this work, a dendritic cell line derived from mouse skin (FSDC) was used, as an in vitro experimental model, to evaluate the cytotoxic effect of two chemical sensitizers, a strong sensitizer (2,4-dinitrofluorobenzene, DNFB) and a weak sensitizer (2,4-dichloronitrobenzene, DCNB). The results indicated that DNFB reduces the cellular metabolism of FSDC, as evaluated by the reduction of the tetrazolium salt, 3-(...
Differential activation of nuclear factor kappa B subunits in a skin dendritic ...
Cruz, MT; Duarte, CB; Gonçalo, Margarida; Figueiredo, A; Carvalho, AP; Lopes, MCDendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large number of genes involved in immune responses, including cytokines and cell surface molecules. In this work, we studied the time-dependent activation of five members ...
Granulocyte-macrophage colony-stimulating factor activates the transcription of...
Cruz, MT; Duarte, CB; Gonçalo, Margarida; Figueiredo, A; Carvalho, AP; Lopes, MCNitric oxide (NO) produced by skin dendritic cells and keratinocytes plays an important role in skin physiology, growth and remodelling. Nitric oxide is also involved in skin inflammatory processes and in modulating antigen presentation (either enhancing or suppressing it). In this study, we found that GM-CSF stimulates the expression of the inducible isoform of nitric oxide synthase (iNOS) in a fetal-skin-deri...
LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dend...
Cruz, MT; Duarte, CB; Gonçalo, Margarida; Carvalho, AP; Lopes, MCThe Janus kinase (JAK) family of protein tyrosine kinases are activated in response to a wide variety of external stimuli. Here we have investigated whether the janus kinase 2 (JAK2) is involved in the induction of nitric oxide synthase type II (iNOS) expression in a mouse fetal skin dendritic cell line (FSDC). In FSDC the expression of iNOS protein and nitric oxide production, in response to the lipopolysaccha...
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in ski...
Cruz, MT; Duarte, CB; Gonçalo, Margarida; Carvalho, AP; Lopes, MCIn this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF)]. Expression of the inducible isoform of NO synthase (iNOS) was confirmed by immunofluorescence with an antibody against iNOS. T...
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