Encontrados 2 documentos, a visualizar página 1 de 1
Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induce...
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. CelesteOur previous studies showed that reactive oxygen species (ROS) are required for the pro-inflammatory cytokine interleukin-1beta (IL-1) to induce the activity of the Nuclear transcription Factor-kappaB (NF-kappaB) and the expression of the inducible isoform of the nitric oxide synthase (iNOS) in bovine articular chondrocytes. This study aimed at elucidating the role of hydrogen peroxide (H2O2) and the superoxide...
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced b...
Mendes, A. Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. CelesteAIMS: In this work, we studied the mechanisms by which diphenyleneiodonium chloride (DPI) inhibits nitric oxide (NO) synthesis induced by the proinflammatory cytokine interleukin-1beta (IL-1) in bovine articular chondrocytes. To achieve this, we evaluated the ability of DPI to inhibit the expression and activity of the inducible isoform of the NO synthase (iNOS) induced by IL-1. We also studied the ability of D...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||