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Regulation of AMPA receptors and synaptic plasticity
Santos, S. D.; Carvalho, A. L.; Caldeira, M. V.; Duarte, C. B.Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracell...
Role of the brain-derived neurotrophic factor at glutamatergic synapses
Carvalho, A. L.; Caldeira, M. V.; Santos, S. D.; Duarte, C. B.The neurotrophin brain-derived neurotrophic factor (BDNF) plays an important role in the activity-dependent regulation of synaptic structure and function, particularly of the glutamatergic synapses. BDNF may be released in the mature form, which activates preferentially TrkB receptors, or as proBDNF, which is coupled to the stimulation of the p75(NTR). In the mature form BDNF induces rapid effects on glutamate ...
Partial purification of tightly bound mitochondrial hexokinase from maize (Zea ...
Rezende,G.L.; Logullo,C.; Meyer,L.; Machado,L.B.; Oliveira-Carvalho,A.L.; Zingali,R.B.; Cifuentes,D.; Galina,A.In mammals, hexokinase (HK) is strategically located at the outer membrane of mitochondria bound to the porin protein. The mitochondrial HK is a crucial modulator of apoptosis and reactive oxygen species generation. In plants, these properties related to HK are unknown. In order to better understand the physiological role of non-cytosolic hexokinase (NC-HK) in plants, we developed a purification strategy here d...
Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors invol...
Santos, A. E.; Duarte, C. B.; Iizuka, M.; Barsoumian, E. L.; Ham, J.; Lopes, M. C.; Carvalho, A. P.; Carvalho, A. L.Cells preferentially expressing GluR4-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors are particularly sensitive to excitotoxicity mediated through non-N-methyl-D-aspartate receptors. However, the excitotoxic signalling pathways associated with GluR4-containing AMPA receptors are not known. In this work, we investigated the downstream signals coupled to excitotoxicity media...
Two African swine fever virus proteins derived from a common precursor exhibit ...
Eulálio, A.; Nunes-Correia, I.; Carvalho, A. L.; Faro, C.; Citovsky, V.; Simões, S.; Lima, M. C. Pedroso deAfrican swine fever virus (ASFV), a large icosahedral deoxyvirus, is the causative agent of an economically relevant hemorrhagic disease that affects domestic pigs. The major purpose of the present study was to investigate the nuclear transport activities of the ASFV p37 and p14 proteins, which result from the proteolytic processing of a common precursor. Experiments were performed by using yeast-based nucleocy...
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