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Induction of antioxidant defences by diterpenic phenolics in human fibroblasts ...

Ageing is characterised by the progressive accumulation of molecular damage, which leads to altered cellular functioning, reduced stress tolerance and susceptibility to diseases. Consumption of fruits, vegetables and herbs has been related with health promotion due to their content in bioactive phytochemicals, which can be used for ageing interventions [1]. In the present work, the ability of the phenolic diter...

Elicitation of Hypericum perforatum cells with Agrobacterium tumefaciens induce...

Hypericum perforatum (HP) commonly known as St. John’s wort is an important medicinal plant traditionally used in several ailments including mild to moderate depression. In a recent study, elicitation of HP cells (culture of cells in suspension) with Agrobacterium tumefaciens (AT) increased significantly the production of compounds with antioxidant and antimicrobial properties [1]. The ability of methanolic ext...

Authors' reply to "Cell therapy in dilated cardiomyopathy: back to the right sc...

Cell therapy in dilated cardiomyopathy: from animal models to clinical trials

Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) even in the absence of a diagnosed primary disease. In ...

Induction of cellular stress responses by phytochemicals for nutritional applic...

Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses and impaired stress responses, reducing the ability of cells to cope with stress. As xenobiotics, we hypothesize that, by imposing mild stress on human cells, antioxidant phytochemicals may afford anti-aging properties through induction of stress responses and cellular ant...

Induction of cellular stress responses by phytochemicals for nutritional applic...

Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses. Under the scope of the undergoing NaturAge project, our group is currently investigating the ability of some plant extracts and isolated phytochemicals to induce antioxidant defenses through Nrf2/ARE signaling. That, will be associated with possible anti-aging effects usi...

Induction of antioxidant defenses by diterpenic phenolics in human fibroblasts ...

Human lifespan is increasing in developed and developing countries, rising considerably the percentage of elderly people. Aging is characterized by the progressive accumulation of molecular damage, which leads to altered cellular functioning, reduced stress tolerance and susceptibility to diseases, such as cancer, neurodegenerative and cardiovascular diseases. Consumption of fruits, vegetables and herbs has bee...

Induction of antioxidant defenses in human HepG2 cells by a methanolic extract ...

Hypericum perforatum (HP) commonly known as St. John’s wort is an important medicinal plant traditionally used in several ailments including mild to moderate depression. In a recent study, elicitation of HP cells (culture of cells in suspension) with Agrobacterium tumefaciens (AT) increased significantly the production of compounds with antioxidant and antimicrobial properties [1]. The present investigation has...

Tailoring elastase inhibition with synthetic peptides

Chronic wounds are the result of excessive amounts of tissue destructive proteases such as human neutrophil elastase (HNE). The high levels of this enzyme found on those types of wounds inactivate the endogenous inhibitor barrier thus, the search for new HNE inhibitors is required. This work presents two new HNE inhibitor peptides, which were synthesized based on the reactive-site loop of the Bowman–Birk inhib...

Human umbilical cord blood cells in infarcted rats

Therapy with bone marrow-derived cells has been used in ischemic patients with reported success. The aim of this study was to determine the therapeutic efficacy of fresh and frozen human umbilical cord blood cells (hUCB) in Wistar rats submitted to permanent occlusion of the left coronary artery. Three hours after myocardial infarction, 2 x 10(7) hUCB cells or vehicle were administered by intramyocardial inject...