Encontrados 17 documentos, a visualizar página 1 de 2
Late onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency: rev...
Vieira, Alexandra; Paiva, Sandra; Baptista, Carla; Ruas, Luísa; Silva, Júlia; Gonçalves, João; Carrilho, Francisco; Carvalheiro, ManuelaThe deficiency of the enzyme 21-hydroxylase (21-HO) is responsible for about 90% to 95% of all cases of congenital adrenal hyperplasia (HCSR). This disorder is one of the most frequent hereditary illnesses of autosomal recessive trait. The illness can be presented in two clinical forms: 1 - classic, subdivided in saltwasting form and simple virilizing form; 2 - nonclassic or late-onset. The severity of the illn...
Recurrent hypercortisolism after removal of an ACTH secretor pituitary adenoma ...
Santos, Jacinta; Paiva, Isabel; Gomes, Leonor; Batista, Carla; Geraldes, Elisabete; Rito, Manuel; Velez, Ana; Oliveira, Fernando; Carvalheiro, ManuelaA 29 years old patient was sent to our Outpatient Clinic of Endocrinology presenting clinic of hypercortisolism. Laboratorial study: High urinary free cortisol (UFC); serum cortisol - 25 microg/dl (8 am) (5-25) and 20 microg/dL (11pm); ACTH - 20 pg/mL (9-52) (8 am) and 14 pg/mL (11 pm); serum cortisol after dexamethasone suppression test: 14,9 mg/dL; CRH test: elevation of ACTH; Pituitary MRI: microadenoma; abd...
Liposomes as nanosystems for the transport and delivery of bioactive agents
Carvalheiro, Manuela Colla, 1967-Tese de doutoramento, Farmácia (Tecnologia Farmacêutica), Universidade de Lisboa, Faculdade de Farmácia, 2011 ; The concept of pharmaceutical nanobiotechnology was originated in the 1970s when liposomes started to be used as nano-drug delivery systems (NanoDDS) to incorporate lipophilic and hydrophilic drugs. Since then liposomes have been the most widely investigated nano-carrier system aiming to achieve cont...
Lack of association of vitamin D receptor gene polymorphisms with susceptibilit...
Lemos, Manuel C.; Fagulha, Ana; Coutinho, Eduarda; Gomes, Leonor; Bastos, Margarida; Barros, Luisa; Carrilho, Francisco; Geraldes, ElizabeteThe vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207...
Diabetic nephropathy: glomerular filtration rate and estimated creatinine clear...
Guimarães, Joana; Bastos, Margarida; Melo, Miguel; Carvalheiro, ManuelaTo assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.There was a strong positive correlation between the two me...
Thyroid lymphoma.
Guimarães, Joana; Rodrigues, Dírcea; Fagulha, Ana; Almeida, Sérgio; Bastos, Margarida; Carvalheiro, ManuelaThyroid Lymphomas are rare tumors among thyroid neoplasms. Almost all types originate from B cells and the most frequent subtype is a diffuse large cell lymphoma. The majority arise in a background of Hashimoto's thyroiditis and patients present with a thyroid mass, rapidly enlarging and with pressure symptoms. The treatment depends on the histological subtype and stage of the disease but include radiotherapy a...
Noninvasive analysis of hepatic glycogen kinetics before and after breakfast wi...
Jones, John G.; Fagulha, Ana; Barosa, Cristina; Bastos, Margarida; Barros, Luisa; Baptista, Carla; Caldeira, M. Madalena; Carvalheiro, ManuelaThe contributions of hepatic glycogenolysis to fasting glucose production and direct pathway to hepatic glycogen synthesis were quantified in eight type 1 diabetic patients and nine healthy control subjects by ingestion of (2)H(2)O and acetaminophen before breakfast followed by analysis of urinary water and acetaminophen glucuronide. After overnight fasting, enrichment of glucuronide position 5 relative to body...
Diabetes in the elderly: our reality.
Paiva, Isabel; Baptista, Carla; Ribeiro, Cristina; Leitão, Patrícia; Carvalheiro, ManuelaTo evaluate the impact of the aging of our population in the growing of diabetes prevalence, among patients treated inward at our department.The clinical files of 242 diabetics older than eighty years, treated between 1999 and 2002 were studied retrospectively. Demographic (sex, age, year of first contact), clinical (causes of admission, co-morbidities, duration of diabetes, previous hypoglycaemic treatment, du...
Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol gluc...
Ribeiro, Angela; Caldeira, M. Madalena; Carvalheiro, Manuela; Bastos, Margarida; Baptista, Carla; Fagulha, Ana; Barros, Luisa; Barosa, CristinaThe contribution of gluconeogenesis to fasting glucose production was determined by a simple measurement of urinary menthol glucuronide (MG) 2H enrichment from 2H2O. Following ingestion of 2H2O (0.5% body water) during an overnight fast and a pharmacological dose (400 mg) of a commercial peppermint oil preparation the next morning, 364 mumol MG was quantitatively recovered from a 2-h urine collection by ether e...
Platelet hyperactivation in maintained growth hormone-deficient childhood patie...
Reis, Flávio; Campos, Maria Vitor; Bastos, Margarida; Almeida, Luis; Lourenço, Margarida; Ferrer-Antunes, Carlos A.; Palmeiro, AidaGH deficiency (GHD) is associated with a higher risk of vascular disease, whose pathophysiological mechanisms remains not yet fully elucidated. This study aimed to assess the main cardiovascular risk indexes, plasma catecholamines content, and the platelet function in childhood-onset GHD patients. Some of the main clinical examinations related with cardiovascular risk, plasma catecholamines content, as well as ...
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