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Involvement of yeast HSP90 isoforms in response to stress and cell death induce...
Silva, Maria Alexandra; Marques, Belém Sampaio; Fernandes, Ângela Margarida Oliveira; Carreto, Laura; Rodrigues, Fernando José dos SantosAcetic acid-induced apoptosis in yeast is accompanied by an impairment of the general protein synthesis machinery, yet paradoxically also by the up-regulation of the two isoforms of the heat shock protein 90 (HSP90) chaperone family, Hsc82p and Hsp82p. Herein, we show that impairment of cap-dependent translation initiation induced by acetic acid is caused by the phosphorylation and inactivation of eIF2 alpha by...
Intra-strain phenotypic and genomic variability of the commercial Saccharomyces...
Duarte, Ricardo Franco; Carreto, Laura; Mendes, Inês; Cambon, Brigitte; Dequin, Sylvie; Santos, Manuel A. S.; Casal, Margarida; Schuller, DoritThe use of commercial Saccharomyces cerevisiae wine strains as fermentation starters has been extensively generalised over the past two decades. These strains are used by wineries every harvest in large quantities. We showed that such strains are disseminated from the winery and their permanence in nature induced genetic changes, not found among a control group of isolates that derived from clonal expansion of ...
Expression variability of co-regulated genes differentiates Saccharomyces cerev...
Carreto, Laura; Eiriz, Maria Francisca; Domingues, Inês; Schuller, Dorit; Moura, Gabriela; Santos, Manuel A. S.Background: Saccharomyces cerevisiae (Baker’s yeast) is found in diverse ecological niches and is characterized by high adaptive potential under challenging environments. In spite of recent advances on the study of yeast genome diversity, little is known about the underlying gene expression plasticity. In order to shed new light onto this biological question, we have compared transcriptome profiles of five envi...
Genetic characterization of commercial Saccharomyces cerevisiae isolates recove...
Duarte, Ricardo Franco; Carreto, Laura; Cambon, Brigitte; Dequin, Sylvie; Santos, Manuel A. S.; Casal, Margarida; Schuller, DoritThe use of commercial S. cerevisiae wine strains as fermentation starters has been extensively generalized over the past two decades. Within our previous work we showed that such strains are disseminated from the winery and their permanence in nature induced genetic changes in comparison to the commercial “mother” strain. The objective of the present study was to evaluate genome variations among four isolates o...
Comparative genomics of commercial Saccharomyces cerevisiae isolates recovered ...
Duarte, Ricardo Franco; Carreto, Laura; Cambon, Brigitte; Dequin, Sylvie; Santos, Manuel A. S.; Casal, Margarida; Schuller, DoritApresentação efetuada nas 36.ª Jornadas Portuguesas de Genética, Coimbra, 2011 ; The use of commercial Saccharomyces cerevisiae wine yeast strains as fermentation starters has been extensively generalised over the past two decades. These strains are used by wineries every year at the harvest time in large quantities. Within our previous work we showed that such strains are disseminated from the winery and can ...
Microevolutionary changes of commercial Saccharomyces cerevisiae strains recove...
Duarte, Ricardo Franco; Carreto, Laura; Cambon, Brigitte; Dequin, Sylvie; Santos, Manuel A. S.; Casal, Margarida; Schuller, DoritThe use of commercial Saccharomyces cerevisiae wine yeast strains as fermentation starters has been extensively generalised over the past two decades. These strains are used by wineries every harvest time in large quantities. Within our previous work we showed that such strains are disseminated from the winery [1] and their permanence in nature induced genetic changes that were not found among a control group o...
Comparative genomics of yeast strains isolated from diverse ecological niches u...
Eiriz, Maria Francisca; Carreto, Laura; Gomes, Ana Catarina; Pereira, Patrícia; Schuller, Dorit; Santos, Manuel A. S.Background: Genome variability generates phenotypic heterogeneity and is of relevance for adaptation to environmental change, but the extent of such variability in natural populations is still poorly understood. For example, selected Saccharomyces cerevisiae strains are variable at the ploidy level, have gene amplifications, changes in chromosome copy number, and gross chromosomal rearrangements. This suggests ...
Transcriptome variability of yeast strains
Carreto, Laura; Schuller, Dorit; Santos, Manuel A. S.Comunicação em forma de painel, apresentado por Laura Carreto
Transcriptome variability in yeast strains
Carreto, Laura; Schuller, Dorit; Santos, Manuel A. S.In order to understand yeast natural genome and transcriptome variability and evaluate whether such variability correlates with phenotypic diversity, we have isolated approximately 1000 yeast strains from Portuguese vineyards, namely from the Bairrada and Minho wine regions, genotyped them and selected the most divergent ones for genome and transcriptome characterization, using comparative genome hybridization ...
Codon-triplet context unveils unique features of the Candida albicans protein c...
Moura, Gabriela; Lousado, José; Pinheiro, Miguel; Carreto, Laura; Silva, Raquel; Oliveira, José; Santos, ManuelBACKGROUND: The evolutionary forces that determine the arrangement of synonymous codons within open reading frames and fine tune mRNA translation efficiency are not yet understood. In order to tackle this question we have carried out a large scale study of codon-triplet contexts in 11 fungal species to unravel associations or relationships between codons present at the ribosome A-, P- and E-sites during each de...
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