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Proliferative mechanisms controlled by nitric oxide in neural stem cells

Neural stem cells proliferate in the adult central nervous system (CNS) in two main regions, the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles. The finding that neural stem cells are able to divide, migrate and differentiate into several cellular types raised a new hope for restorative neurology. Nitric oxide (NO), a pleiotropic s...