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Changes in calcium dynamics following the reversal of the sodium-calcium exchan...
Araújo, I. M.; Carreira, B. P.; Pereira, T.; Santos, P. F.; Soulet, D.; Inácio, A.; Bahr, B. A.; Carvalho, A. P.; Carvalho, C. M.Proteolytic cleavage of the Na(+)/Ca(2+) exchanger (NCX) by calpains impairs calcium homeostasis, leading to a delayed calcium overload and excitotoxic cell death. However, it is not known whether reversal of the exchanger contributes to activate calpains and trigger neuronal death. We investigated the role of the reversal of the NCX in Ca(2+) dynamics, calpain activation and cell viability, in alpha-amino-3-hy...
Data: 2007
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Origem: Estudo Geral - Universidade de Coimbra
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