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Allogeneic stem cell transplantation in patients with myelodysplastic syndrome:...

We determined the outcome of patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML) after allogeneic stem cell transplantation according to their international prognostic scoring system (IPSS) risk categories at diagnosis. A total of 11 females and 7 males, with a median age of 45 years, were transplanted. With a median follow-up of 60 months, the 6-year actuarial event-free su...

Paraquat exposure as an etiological factor of Parkinson's disease

Treatment of acute promyelocytic leukemia with trans-retinoic acid. Experience ...

Acute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia that is usually associated with a fatal hemorrhagic diathesis. All trans-retinoic acid (ATRA) is an active metabolite of vitamin A that differentiates the malignant cell clone, corrects the coagulopathy, and induces complete remission in the vast majority of patients with APL. Between June 1992 and September 1993, 8 patients with...

Acute promyelocytic leukemia. The therapeutic advances.

Acute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia. It is frequently associated with a life-threatening hemorrhagic diathesis, often aggravated by induction cytotoxic chemotherapy. Patients with APL have bone marrow infiltration by abnormal promyelocytes, usually with prominent cytoplasmic granulation. These patients have a unique cytogenetic abnormality, a balanced reciprocal tr...

Unusual form of presentation of acute monocytic leukemia. Report of a clinical ...

The authors describe an acute monocytic leukemia (M5) developed in a 16-year-old boy with febril syndrome, aortic valve vegetations, bicytopenia and dismyelopoieses. ; The authors describe an acute monocytic leukemia (M5) developed in a 16-year-old boy with febril syndrome, aortic valve vegetations, bicytopenia and dismyelopoieses.