Mestrado em Reabilitação Psicomotora ; O presente documento tem como objetivo a descrição do trabalho desenvolvido durante o Estágio Profissionalizante, inserido no Ramo de Aprofundamento de Competências Profissionais do Mestrado de Reabilitação Psicomotora (2º Ciclo) da Faculdade de Motricidade Humana e realizado no âmbito da Psicomotricidade e Intervenção Precoce. O estágio decorreu na Equipa MÃ...
Virgin olive oil (VOO) has many potential health benefits, including the amelioration of inflammatory processes. In part, this is known to occur through the modification of the endothelial function, leading to a decrease of the levels of cell-adhesion molecules (CAMs), including the inter-cellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1). Importantly, virgin olive oil is a...
A growing body of evidence suggests that mitochondrial proton-leak functions as a regulator of reactive oxygen species production and its modulation may limit oxidative injury to tissues. The main purpose of this work was to characterize the proton-leak of brain cortical mitochondria from long-term hyperglycemic and insulininduced recurrent hypoglycemic rats through the modulation of the uncoupling protein 2 (U...
In the last decades, oxidative stress has been recognized as a key process in the physiopathology of several diseases. Consequently, the search for new antioxidant compounds, as well as new antioxidant sources, has increased exponentially. The Lamiaceae family encloses many plant species which are potential sources of antioxidant compounds. The present study evaluates the antioxidant activity of phenolic enrich...
The present study investigated the antioxidant and cytoprotective effects of purified ethanolic extracts of Cytisus multiflorus, Lamium album L. and Thymus citriodorus plants. These extracts showed high antioxidant activity in DPPH and reducing power assays. Using a model of chemical stress induced by potassium dichromate (DK) in human hepatoblastoma HepG2 cells, 50 ug/mL of C. multiflorus, L. album and T. citr...
Mentha and Thymus are important genera of the Lamiaceae family widely distributed in the entire World and commonly used in traditional medicine. Indeed, many species of the two genera have been credited with a large list of health-benefit effects, including antioxidant, anti-inflammatory, antimicrobial, analgesic, neuroprotective and anticarcinogenic. In turn, these properties have been associated to the polyph...
Thymus x citriodorus is a Lamiaceae plant extensively cultivated in Mediterranean region and used for centuries in culinary and in traditional medicine. The present work describes the detailed phenolic composition of T. x citriodorus for the first time, the by means of HPLC-DAD, ESI-MS and MSn and nuclear magnetic resonance (NMR) analyses. The ethanolic extract of T. x citriodorus was analyzed by reversed phase...
Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L album L is far from being understood. In this study, a purified ethanolic extract (PEEL)...
The present study investigates the phenolic composition and the antioxidant capacity of an ethanolic extract from flowers of C. multiflorus. As determined by HPLC-DAD, ESI-MSn and NMR combined analysis, this extract was mainly composed of chrysin-7-O-β-D-glycopyranoside, and also contained considerable amounts of rutin, a dihydroxyflavone isomer of chrysin and glycosidic derivatives of luteolin and apigenin. Th...
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