Encontrados 3 documentos, a visualizar página 1 de 1
Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–4...
Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Cláudia F.Neurovascular dysfunction arising from endothelial cell damage is an early pathogenic event that contributes to the neurodegenerative process occurring in Alzheimer's disease (AD). Since the mechanisms underlying endothelial dysfunction are not fully elucidated, this study was aimed to explore the hypothesis that brain endothelial cell death is induced upon the sustained activation of the endoplasmic reticulum ...
Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole...
Keri, Rangappa S.; Quintanova, Catarina; Marques, Sérgio M.; Esteves, A. Raquel; Cardoso, Sandra M.; Santos, M. AméliaAlzheimer’s disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of ...
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity
Cardoso, Sandra M.; Santana, Isabel; Swerdlow, Russell H.; Oliveira, Catarina R.Alzheimer's disease (AD) brain reveals high rates of oxygen consumption and oxidative stress, altered antioxidant defences, increased oxidized polyunsaturated fatty acids, and elevated transition metal ions. Mitochondrial dysfunction in AD is perhaps relevant to these observations, as such may contribute to neurodegenerative cell death through the formation of reactive oxygen species (ROS) and the release of mo...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||