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Preparation of ethylcellulose/methylcellulose blends by supercritical antisolve...
Duarte, Ana Rita C.; Gordillo, M. D.; Cardoso, M. Margarida; Simplicio, A. L.; Duarte, Catarina M. M.The supercritical antisolvent (SAS) techniquewas used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This lead...
Preparation of controlled release microspheres using supercritical fluid techno...
Duarte, Ana Rita C.; Costa, M. S.; Simplicio, A. L.; Cardoso, M. Margarida; Duarte, Catarina M. M.Ethylcellulose/methylcellulose blends were produced using different precipitation techniques and impregnated with naproxen, a non-steroidal anti-inflammatory drug (NSAID). Solvent-evaporation technique was used not only for the preparation of ethylcellulose/methylcellulose microspheres but also to encapsulate naproxen. Supercritical fluid (SCF) impregnation was also performed to prepare naproxen loaded microsph...
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