Recent reports showed promising results with topical beta-blocker therapy for ulcerated infantile hemangiomas.The authors report the case of a 6-month-old preterm girl with an ulcerated infantile hemangioma of the intergluteal cleft successfully treated with topical timolol. ; Dados recentes revelam resultados promissores com a utilização de beta-bloqueante tópico no tratamento dos hemangiomas infantis ulcerad...
About 30% of adults with morphea have a simultaneous autoimmune disease, which may support the involvement of autoimmunity in the pathogenesis of this fibrosing disorder of the skin and underlying tissues.A 27-year-old man presented with an asymptomatic, erythematous, slightly depressed, indurated oval plaque on the abdominal region that had been present for 1 year. Another dermatological finding was acro-facia...
Erythema multiforme is an uncommon, immune-mediated disorder that presents with cutaneous or mucosal lesions or both, that occurs as a hypersensitivity reaction in response to infections or drugs. Erythema multiforme is mostly associated with herpes simplex virus. The association with Mycobaterium tuberculosis infection was less frequently described. We present a case of an Erythema multiforme caused by Mycobac...
Statins are widely used nowadays. They are usually safe but sometimes can be associated with the development/ worsening of autoimmune diseases like Cutaneous Lupus Erythematosus. Authors describe the case of a female caucasian patient, 74 years-old, that 18 months after initiating therapy with simvastatin developed an annular skin rash on back and shoulders, characterized by erythematous papules and plaques wit...
Potential effects of pregnancy-associated hormones, endogenous and exogenous hormones on melanocytic nevi have been known for years. A 35-year-old man presented with a 6 month history of fast and simultaneous growth of previous, multiple melanocytic nevi located on the trunk, associated with increased levels of beta-human chorionic gonadotropin derived from testicular seminoma. After radical orchiectomy and adj...
The coexistence of more than one neoplasm in a single cutaneous specimen is uncommon and has been defined as collision or compound tumor. The authors describe a 66-year-old man who presented with a contiguous seborrheic keratosis and a basal cell carcinoma on the left malar region that had developed in about one year. The case was investigated clinically and focusing on the dermoscopic features and histopatholo...
A wide variety of pathogenically unrelated skin diseases may follow a zosteriform distribution pattern. Zosteriform morphea is a rare and recently described pattern of presentation of this localized sclerosis of the skin. We report the case of a 26-year old woman with morphea presenting with a zosteriform pattern without a preceding herpes zoster infection. She was treated with topical PUVA for a total of 10 se...
Tese de doutoramento em Tecnologias e Sistemas de Informação
Public digital displays are moving towards open display networks, resulting in a shift in the focus from single-purpose public displays that are developed with a single task or application in mind, to general- purpose displays that can run several applications, developed by different vendors. In this new paradigm, it is important to facilitate the development of interactive public display applications and provi...
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