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Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class...
Cardoso, J. C. R.; Félix, Rute C.; Power, DeborahNematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. The present study reevaluates the evolution of metazoan Class 2 B1 GPCRs and orthologues by exploring the...
Feeding and the rhodopsin family g-protein coupled receptors in nematodes and a...
Cardoso, J. C. R.; Félix, Rute C.; Fonseca, Vera G.; Power, DeborahIn vertebrates, receptors of the rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut axis.These peptides regulate appetite and energy expenditure by promoting or inhibiting food intake. Sequence and function homologs of human GPCRs involved in feeding exist in the nematode round...
Gene structure, transcripts and calciotropic effects of the PTH family of pepti...
Pinheiro, Pedro L. C.; Cardoso, J. C. R.; Gomes, Ana S.; Fuentes, Juan; Power, Deborah; Canario, Adelino V. M.Background: Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal development. Recently, PTH-like peptide (PTH-L) was identified in teleost fish raising questions about the evolution of these proteins. Although PTH and PTHrP have be...
The serendipitous origin of chordate secretin peptide family members
Cardoso, J. C. R.; Vieira, Florbela A.; Gomes, Ana S.; Power, DeborahBackground: The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications. In human, 10 members exist and sequence and functional homologues and ligand-receptor pairs have been characterised in representatives of most vertebrate classes. Secreti...
Persistence of duplicated PAC(1) receptors in the teleost, Sparus auratus
Cardoso, J. C. R.; Vet, Edwin C. J. M. de; Louro, Bruno; Elgar, Greg; Clar, M. S.; Power, DeborahBackground: Duplicated genes are common in vertebrate genomes. Their persistence is assumed to be either a consequence of gain of novel function (neofunctionalisation) or partitioning of the function of the ancestral molecule (sub-functionalisation). Surprisingly few studies have evaluated the extent of such modifications despite the numerous duplicated receptor and ligand genes identified in vertebrate genomes...
Isolation of a novel aquaglyceroporin from a marine teleost (Sparus auratus) Fu...
Santos, C. R. A.; Estêvão, M. D.; Fuentes, J.; Cardoso, J. C. R.; Fabra, M.; Passos, A. L.; Detmers, F. J.; Deen, P. M. T.; Cerdà, J.; Power, DeborahThe aquaporins (formerly called the major intrinsic protein family) are transmembrane channel proteins. The family includes the CHIP group, which are functionally characterised as water channels and the GLP group, which are specialised for glycerol transport. The present study reports the identification and characterisation of a novel GLP family member in a teleost fish, the sea bream Sparus auratus. A sea brea...
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