Encontrados 2 documentos, a visualizar página 1 de 1
Application of Thermoresponsive PNIPAAM‑b‑PAMPTMA Diblock Copolymers in siRNA D...
Cardoso, Ana M.; Calejo, M. Teresa; Morais, Catarina M.; Cardoso, Ana L.; Cruz, Rita; Zhu, Kaizheng; de Lima, M. C. P.; Jurado, A. S.; Nyström, BoGene knockdown has emerged as an important tool for cancer gene therapy as well as for viral infections and dominantly inherited genetic disorders. The generation of suitable siRNA delivery systems poses some challenges, namely, to avoid nuclease degradation, to surpass the cytoplasmic membrane, and to release the nucleic acids into the cytosol. Aiming at evaluating the ability of thermoresponsive block copolym...
S4(13)-PV cell-penetrating peptide induces physical and morphological changes i...
Cardoso, Ana M. S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; Lúcio, Marlene; Reis, SaletteThe present work aims to gain insights into the role of peptide–lipid interactions in the mechanisms of cellular internalization and endosomal escape of the S4(13)-PV cell-penetrating peptide, which has been successfully used in our laboratory as a nucleic acid delivery system. A S4(13)-PV analogue, S4(13)-PVscr, displaying a scrambled amino acid sequence, deficient cell internalization and drug delivery inabil...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||