Encontrados 10 documentos, a visualizar página 1 de 1
Factores associados à hipertensão arterial nos utentes de farmácias em Portugal
Oliveira-Martins,Sofia de; Oliveira,Tiago; Gomes,João J F; Caramona,Margarida; Cabrita,JoséOBJETIVO: Estimar a prevalência, tratamento e controlo da hipertensão e identificar factores associados em utentes de farmácias comunitárias. MÉTODOS: Estudo transversal com 1.042 utentes de 40 a 65 anos em 60 farmácias comunitárias de Portugal Continental entre outubro de 2005 e janeiro de 2006. Os dados foram obtidos pela aplicação de questionário e medição de parâmetros biológicos. Foram realizadas três regr...
Stereoselective Disposition of S- and R-Licarbazepine in Mice
Alves, Gilberto; Figueiredo, Isabel; Falcão, Amílcar; Castel-Branco, Margarida; Caramona, Margarida; Soares-da-Silva, PatrícioThe stereoselective disposition of S-licarbazepine (S-Lic) and R-licarbazepine (R-Lic) was investigated in plasma, brain, liver, and kidney tissues after their individual administration (350 mg/kg) to mice by oral gavage. Plasma, brain, liver, and kidney concentrations of licarbazepine enantiomers and their metabolites were determined over the time by a validated chiral HPLC-UV method. The mean concentration da...
Stereoselective disposition of S and R-licarbazepine in mice
Alves, Gilberto; Figueiredo, Isabel; Falcão, Amílcar; Castel-Branco, Margarida; Caramona, Margarida; Soares-da-Silva, PatrícioThe stereoselective disposition of S-licarbazepine (S-Lic) and R-licarbazepine (R-Lic) was investigated in plasma, brain, liver, and kidney tissues after their individual administration (350 mg/kg) to mice by oral gavage. Plasma, brain, liver, and kidney concentrations of licarbazepine enantiomers and their metabolites were determined over the time by a validated chiral HPLC-UV method. The mean concentration da...
Assessment of global cardiovascular risk and risk factors in Portugal according...
Martins, Sofia de Oliveira; Silva, Polybio Serra e; Papoila, Ana; Caramona, Margarida; Mil, Jan Foppe van; Cabrita, JoséAbstract Background/objective Cardiovascular diseases (CVD) are the leading cause of mortality in European countries. This study aimed at estimating the 10-year risk of fatal CVD in Portuguese adults and to assess the prevalence of major cardiovascular risk factors, according to the SCORE® risk prediction system. Subjects and methods A cross-sectional survey was carried out in 60 community pharmacies (CP) ...
Performance of gentamicin population kinetic parameters in Portuguese neonates
Rocha, Marília J.; Almeida, Anabela M.; Falcão, Amílcar C.; Caramona, Margarida M.Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA), receiving gentamicin, and for whom peak and trough concentrations were obtained. Accuracy and precision were assessed by mean...
Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (B...
Alves, Gilberto; Figueiredo, Isabel; Castel-Branco, Margarida; Loureiro, Ana; Fortuna, Ana; Falcão, Amílcar; Caramona, MargaridaEslicarbazepine acetate (BIA 2-093) is a novel central nervous system drug undergoing clinical phase III trials for epilepsy and phase II trials for bipolar disorder. A simple and reliable chiral reversed-phase HPLC-UV method was developed and validated for the simultaneous determination of eslicarbazepine acetate, oxcarbazepine, S-licarbazepine and R-licarbazepine in human plasma. The analytes and internal sta...
Simultaneous and enantioselective liquid chromatographic determination of eslic...
Alves, Gilberto; Figueiredo, Isabel; Castel-Branco, Margarida; Loureiro, Ana; Falcão, Amílcar; Caramona, MargaridaHerein is reported, for the first time, a simple and reliable chiral reversed-phase liquid chromatographic method coupled to ultraviolet (UV) detection for simultaneous determination of eslicarbazepine acetate (ESL) and its metabolites, S-licarbazepine (S-LC), R-licarbazepine (R-LC) and oxcarbazepine (OXC), in mouse plasma and brain, liver and kidney tissue homogenates. All analytes and the internal standard we...
Performance of gentamicin population kinetic parameters in Portuguese neonates
Rocha, Marília J.; Almeida, Anabela M.; Falcão, Amílcar; Caramona, Margarida M.Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA), receiving gentamicin, and for whom peak and trough concentrations were obtained. Accuracy and precision were assessed by mean...
Complexos de inclusão de indometacina com hidroxipropil-β- ciclodextrina. Estud...
Rama, Ana Cristina Ribeiro; Veiga, Francisco; Figueiredo, Isabel Vitória; Sousa, Adriano; Caramona, MargaridaA indometacina, antiinflamatório não-esteróide, é praticamente insolúvel em água. A hidroxipropil-β-ciclodextrina confere aos fármacos nela incluídos melhores características de solubilidade. A formação de complexos com indometacina protege da hidrólise, aumentando a solubilidade. O objetivo desse trabalho foi estudar a influência da complexação por liofilização e por spray-dried, na dissolução e coeficiente de...
Relationship between plasma and brain levels and the anticonvulsant effect of l...
Castel-Branco, Margarida; Lebre, Vera; Falcão, Amílcar; Figueiredo, Isabel; Caramona, MargaridaThe aims of the present research were to characterize the plasma and brain concentration–time profiles of lamotrigine after its acute administration and to establish the relationship between these profiles and the anticonvulsant effect of lamotrigine in rats. Adult male Wistar rats were given 10 mg/kg of lamotrigine intraperitoneally. The lamotrigine profiles in plasma and brain were determined at predetermined...
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