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The maximal electroshock seizure (MES) model in the preclinical assessment of p...

The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...

The maximal electroshock seizure (MES) model in the preclinical assessment of p...

The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...

Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...

Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...

Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...

Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...

Pharmacological properties of Tilia europeæ aqueous: screening anxiolytic/sedat...

The extracts or infusions obtained from inflorescences of Tilia europeae have been used in popular medicine as a sedative/anxiolytic drug. The purpose of the present work was to evaluate these possible properties of this extract, by using different behavioural models. The extract, orally administered to mice, prolonged sleeping time, changed the level of anxiety, affected curiosity and locomotor activity and sh...

Monoamine Oxidase Type A and B activities in human uterine arteries: influence ...

Behavioural Tests to Identify Anxiolytic Activity of Drugs

Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular ...

The pro-inflammatory cytokine interleukin-1ß (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. This study aimed at elucidating the role of ROS, particularly H2O2, in mediating IL-1-induced activation of the transcription factor activator protein-1 (AP-1) in primary cultures of articular chondrocytes. AP-...

Lamotrigine analysis in blood and brain by high-performance liquid chromatography

A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...

Lamotrigine analysis in blood and brain by high-performance liquid chromatography

A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...