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Adenosine A1 receptors inhibit Ca2+ channels coupled to the release of ACh, but...
Santos, Paulo F.; Caramelo, Olga L.; Carvalho, Arsélio P.; Duarte, Carlos B.We investigated the effect of adenosine A1 receptors on the release of acetylcholine (ACh) and GABA, and on the intracellular calcium concentration ([Ca2+]i) response in cultured chick amacrine-like neurons, stimulated by KCl depolarization. The KCl-induced release of [3H]ACh, but not the release of [14C]GABA, was potentiated when adenosine A1 receptor activation was prevented by perfusing the cells with adenos...
Characterization of ATP release from cultures enriched in cholinergic amacrine-...
Santos, Paulo F.; Caramelo, Olga L.; Carvalho, Arsélio P.; Duarte, Carlos B.Adenosine triphosphate (ATP) has been proposed to play a role as a neurotransmitter in the retina, but not much attention has been given to the regulation of ATP release from retinal neurons. In this work, we investigated the release of ATP from cultures enriched in amacrine-like neurons. Depolarization of the cells with KCl, or activation of alpha-amino-3-hydroxy- 5-methyl-4-isoxazole-propionate (AMPA) recepto...
Metabotropic glutamate receptors modulate [3H]acetylcholine release from cultur...
Caramelo, Olga L.; Santos, Paulo F.; Carvalho, Arsélio P.; Duarte, Carlos B.Retinal amacrine cells express metabotropic glutamate receptors (mGluRs), but their physiological role is unknown. We investigated the effect of mGluR on [3H]acetylcholine release ([3H]ACh) from cultured chick amacrine-like neurons. Activation of group III mGluR with the agonist L(+)-2-amino-4-phosphonobutyric acid (L-AP4) inhibited [3H]ACh release evoked by 25 mM KCl in a dose-dependent manner, and this effect...
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