Encontrados 7 documentos, a visualizar página 1 de 1
Carbon Nanotubes – Interactions with Biological Systems
Reis, Joana; Capela-Silva, Fernando; Potes, José; Fonseca, Alexandra; Oliveira, Mónica; Kanagaraj, Subramani; Torres Marques, Antóniohis book chapter discusses the prospective biomedical applications of carbon nanotubes based materials, the impact of carbon nanotubes properties in the interaction with biological systems. Protein adsorption, impact on cell viability and cytokine production are explored. Potential respiratory and dermal toxicity are reviewed, as the difficulties on studying the biological response. In face of recent studies, s...
In vitro studies of multiwalled carbon nanotube/ultrahigh molecular weight poly...
Reis, Joana; Kanagaraj, Subramani; Capela Silva, Fernando; Pereira, Alfredo; Potes, José; Mathew, MT; Simões, JoséCarbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwalled carbon nanotubes in biomaterials contacting with bone. However, carbon nanotubes are also controversial in regards to effects exerted on living organisms. Carbon nanotubes can be used to improve the tribological properties of polym...
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation
Frias, Clara; Reis, Joana; Capela silva, Fernando; Potes, José; Torres Marques, António; Simões, JoséAbstract Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to...
Piezoelectric actuator: searching inspiration in nature for osteoblast stimulation
Frias, Clara; Reis, Joana; Capela Silva, Fernando; Potes, José; Torres Marques, António; Simões, JoséAbstract Bone is a composite with piezoelectric properties. Bone mass and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels, but the role piezoelectricity plays in bone physiology is yet to be understood. Physical activity enhances bone density, through mechanical stimulation. Osteocytes and osteoblasts are essential for mechanosensing and mechanotransduction. Str...
Sterilization of an Electronical Medical Device
Reis, Joana; Cabo Verde, Sandra; Capela Silva, Fernando; Potes, José; Melo, Rita; Nunes, Inês; Marcos, Helena; Silva, Telma; Botelho, Maria LuísaRadiosterilization was applied to a medical device with a “programmable memory” to allow in vivo implantation. Irradiation on a Cobalt-60 facility at 25 kGy at a dose rate of 2kGy/h corrupted the memory. Therefore an alternative sterilization method using UV was developed and validated based on ISO 11737-1 and ISO 14937. These procedures may be useful and effective for research purposes when only a small number...
Sterilization of an Electronic Medical Device
Reis, Joana; Cabo Verde, Sandra; Capela Silva, Fernando; Frias, Clara; Potes, José; Melo, Rita; Nunes, Inês; Marcos, Helena; Silva, TelmaRadiosterilization was applied to a medical device with a “programmable memory” to allow in vivo implantation. Irradiation on a Cobalt-60 facility at 25 kGy at a dose rate of 2kGy/h corrupted the memory. Therefore an alternative sterilization method using UV was developed and validated based on ISO 11737-1 and ISO 14937. These procedures may be useful and effective for research purposes when only a small number...
Piezoelectric bone stimulation: should we move closer to nature?
Reis, Joana; Frias, Clara; Capela-Silva, Fernando; Potes, José; Simões, José; Torres Marques, AntónioThe aim of this work was to experimentally validate the use of piezoelectric materials as a mean of directly straining bone cells by converse piezoelectric effect.
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