Encontrados 22 documentos, a visualizar página 1 de 3
Isoenzymatic expression of Na, K-ATPase in Langerhans islets of glucose intoler...
Costa, Ana R; Capela e Silva, Fernando; Antunes, Célia M; Cruz Morais, Júlio MNa,K-ATPase is ubiquitously expressed in all eukaryotic cells where it acts as a regulator of Na+ and K+ homeostasis. The Na,K-ATPase pump consists of (αβ)22. The α-subunit contains the catalytic and ligand binding sites. The β-subunit is a glycosylated protein, and its role in Na,K-ATPase enzyme function remains somewhat obscure. Four α- and three β-isoforms have been described in mammals. The isoenzymatic exp...
IN VITRO AND IN VIVO REMOVAL OF ORAL ANTIDIABETIC AGENTS (METFORMIN) USING ACTI...
Valente Nabais, Joao; Galacho, Cristina; Galego, Angela; Costa, Ana; Antunes, Celia; Capela e Silva, FernandoDiabetes is the most worldwide common chronic disease, according the International Diabetes Federation [1], more than 32 million citizens living in the European Union have diabetes, representing nearly 10% of the population, to which we should add equal number of people suffering from impaired glucose tolerance. Diabetes prevalence is growing at alarming rate worldwide, being of particular relevance the type 2 ...
Key role of AMPK in glucose-evoked Na,K-ATPase modulation
Rodrigues Costa, Ana; Capela e Silva, Fernando; Antunes, Célia; Cruz-Morais, JúlioBackground and aims: Na,K-ATPase is an integral membrane protein responsible for generating and maintaining transmembrane ionic gradients. It has been demonstrated that, in pancreatic β-cells, Na,K-ATPase is regulated by glucose and that this phenomenon is impaired in glucose intolerant subjects. However, the mechanism underlying glucose-induced modulation of Na,K-ATPase is still unclear. The AMP-activated prot...
The Effect of Tannins on Mediterranean Ruminant Ingestive Behavior: The Role of...
Lamy, Elsa; Rawel, Harshadrai; Schweigert, Florian J.; Capela e Silva, Fernando; Ferreira, Ana; Costa, Ana Rodrigues; Antunes, CéliaAbstract: Sheep, cattle and goat are domestic ruminants of significant economic interest in the Mediterranean region. Although sharing the same pasture ranges, they ingest different plants and plant parts and, consequently different levels of tannins. This suggests an ability to detect and adapt ingestion according to animal physiological limits of tolerance for plant secondary metabolites. This review will det...
BONE MECHANOTRANSDUCTION: A REVIEW
Reis, Joana; Capela e Silva, Fernando; Queiroga, MC; Lucena, Sónia; Potes, JoséThis review focus on the bone physiology and mechanotransduction elements and mechanisms. Bone biology and architecture is deeply related to the mechanical environment. Orthopaedic implants cause profound changes in the biomechanics and electrophysiology of the skeleton. In the context of biomedical engineering, a deep reflexion on bone physiology and electromechanics is needed. Strategic development of new bio...
Learning and teaching histology: traditional and computational methods
Capela e Silva, Fernando; Rato, Luis Miguel; Lopes, Orlando SilvaThe traditional methodology used in histology laboratory instruction of histology is based primarily on the use of photonic microscopes and histological slides, which did not allow the simultaneous observation by several people, prevents an interactive discussion, making the laboratory teaching-learning process less motivating and advantageous. The use of various computer-based technologies (including virtual m...
Osteoblast mechanical stimulation by converse piezoelectric effect.
Reis, Joana; Frias, Clara; Capela e Silva, Fernando; Potes, José; Simões, António; Marques, AntónioThe aim of this work was to experimentally validate the use of piezoelectric materials as a mean of directly straining bone cells by converse piezoelectric effect.
Integrated biomimetic carbon nanotube composites for in vivo systems
Singh, Manoj Kumar; Gracio, Jose; LeDuc, Philip; Gonçalves, Paula P.; Marques, Paula A. A. P.; Gonçalves, Gil; Marques, Filipa; Silva, Virgilia S.As interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and chemical characteris...
Sheep and goat saliva proteome analysis: A useful tool for ingestive behavior r...
Capela e Silva, Fernando; Lamy, Elsa; Costa, G.; Santos, R.; Potes, José; Pereira, Alfredo; Coelho, Ana V.; Sales Baptista, ElviraSheep and goats differ in diet selection, which may reflect different abilities to deal with the ingestion of plant secondary metabolites. Although saliva provides a basis for immediate oral information via sensory cues and also a mechanism for detoxification, our understanding of the role of saliva in the pre-gastric control of the intake of herbivores is rudimentary. Salivary proteins have important biologica...
Experimental and Numerical simulation of mechanical actuators coated with PMMA ...
Frias, Clara; Reis, Joana; Capela e Silva, Fernando; Potes, José; Torres Marques, António; Simões, José AntónioBone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. The aim of this work was to experimentally validate the possibility of using piezoelectric materials as a mean of stimulating mechanically ...
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