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Disseminação de isolados de Enterobacteriaceae produtores da carbapenemase KPC-3

Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinic...

The clinical Klebsiella pneumoniae INSRA6884 strain exhibited nonsusceptibility to all penicillins tested (MICs of 64 to>2,048 g/ml). The MICs of penicillins were weakly reduced by clavulanate (from 2,048 to 512 g/ml), and tazobactam restored piperacillin susceptibility. Molecular characterization identified the genes blaGES-7 and a new -lactamase gene, blaSHV-107, which encoded an enzyme that differed from SH...

Resultados laboratoriais da suscetibilidade aos antibióticos através dos partic...

Identification of the new variant QepA3, a plasmid-mediated quinolone resistanc...

Objectives: The efflux pump QepA confers decreased susceptibility to hydrophilic fluoroquinolones (e.g., norfloxacin, ciprofloxacin, and enrofloxacin). In this study, we characterized the third variant, named qepA3, collected from an Escherichia coli isolate in Portugal. Methods: INSRA6015 was isolated in 2005 from the urine of a 77-year-old female patient hospitalized at the Hospital Fernando Fonseca, Portugal...

Zoonotic potential of multidrug resistant Escherichia coli clonal groups in Por...

Objectives: Multidrug-resistant (MDR) plasmids together with clonal dissemination of resistant isolates are possibly the most successful combination of factors contributing to the spread of antibiotic resistance genes. Our aim was to identify clones associated with multidrug-resistance among human and dolphin isolates, in order to evaluate zoonotic potential and risk. Methods: Sixty two MDR human Escherichia co...

Carbapenemase-producing Enterobacteriaceae isolates collected in Portuguese hos...

Objectives: In Portugal, little is known on carbapenemase (CARB)-producing Enterobacteriaceae. The aim of this study was to identify the resistance mechanisms of Enterobacteriaceae isolates, identified at hospital laboratories as carbapenem (CA) non-susceptible. Methods: This study included 61 Enterobacteriaceae isolates (26 Klebsiella spp, 15 Escherichia coli, 9 Enterobacter spp, 6 Morganella morgannii, 4 Prot...

Phenotypic and molecular characterization of CMY-46 and CMY-50, two novel plasm...

Objectives: The identification of isolates containing AmpC β-lactamases is epidemiologically and clinically relevant. With this study we performed the phenotypic and molecular characterization of two new CMY-2-types, designated CMY-46 and CMY-50, encountered among a total of 1664 clinical non-duplicate isolates of various Enterobacteriaceae species. Methods: E. coli INSRA1169 and INSRA3413 were isolated from t...

Multilocus Sequence Typing of Vancomycin-Resistant Enterococcus faecium isolate...

Vancomycin-resistant enterococci (VRE) first appeared in the late 1980s in a few European countries. In the last two decades, however, vancomycin-resistant Enterococcus faecium (VREfm) as became an emergent and challenging nosocomial problem. Specific clonal groups of E. faecium show an enhanced capacity to disseminate in the nosocomial setting. These strains can be assigned to distinct clonal groups or complex...

Accessing the molecular basis of transferable quinolone resistance in Escherich...

Background: Salmonella and Escherichia coli resistant to quinolones frequently arise in animals, being easily transferred to humans through the food chain, which can ultimately lead to the development of untreatable infectious diseases. The aim of the present study was to investigate the presence of PMQR determinants among Salmonella spp and E. coli from food-producing animals and derivative food products. Meth...

Diversity of β-lactamase-encoding genes among Gram-negative isolates from water...

Water has been recognized as a reservoir for antibiotic resistance genes (ARG), where the presence of mobile genetic elements, including plasmids, favors their dissemination. It is noteworthy that non- pathogenic environmental organisms, where plasmids encoding multiple ARG are prevalent, can provide resistance to most classes of antimicrobials including :-lactams, aminog...