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Prophylactic Mastectomy: still a controversial procedure?

The follow up and care of BRCA1/2 women, and the decisions concerning risk reduction strategies, challenge the classical patient-doctor relationship. Non-directive counseling with open discussion about different alternatives for breast cancer risk reduction is usually recommended. Scientific evidence in this field is complex, due to the lack of randomized data and heterogeneous selection criteria for different ...

2-DIGE of Red Blood Cells from Sickle-Cell Disease Patients with Severe Vaso-Oc...

Proteomics in biomarkers discovery for Obstructive Sleep Apnea

A possible approach for gel-based proteomic studies in recalcitrant woody plants

Woody plants are particularly difficult to investigate due to high phenolic, resin, and tannin contents and laborious sample preparation. In particular, protein isolation from woody plants for two-dimensional gel electrophoresis (2-DE) is challenging as secondary metabolites negatively interfere with protein extraction and separation. In this study, three protein extraction protocols, using TCA, phenol and etha...

Plasma and red blood cell proteome in sickle-cell disease

Sickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection. Painful crises are the major SCD clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies, we aim to di...

Optimizing the discovery of predictors of vaso-occlusion in sickle-cell disease...

Painful crises are the major sickle-cell disease (SCD) clinical manifestation probably due to significant increase in dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using proteomic strategies (see figure below), we aimed to discover novel SCD prognosis biomarkers as early predictors of the transition from steady-state to vaso-occlusive crises thus, allowing a prompt and...

Tobacco smoke occupational exposure: biomarkers of biological damage

High concentration of toxic substances emanated from tobacco smoke in entertainment places such as restaurants, bars and nightclubs may compromise indoor air quality (IAQ) generating environments of likelihood health risk. Their employees, particularly those exposed to second-hand smoke, are at increased risk for developing chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthm...

Concretização do processo de Bolonha e ajustamentos na docência universitária: ...