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Modification upon aging of the density of presynaptic modulation systems in the...
Canas, Paula M.; Duarte, João M. N.; Rodrigues, Ricardo J.; Köfalvi, Attila; Cunha, Rodrigo A.Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve te...
Modification of adenosine modulation of acetylcholine release in the hippocampu...
Rodrigues, Ricardo J.; Canas, Paula M.; Lopes, Luísa V.; Oliveira, Catarina R.; Cunha, Rodrigo A.Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs. Since A2AR antagonists attenuate memory deficits in aged animals and memory deficits might involve a decreased cholinergic function, we investigated how aging affects the density and function of adenosine receptors in rat hippocampal cholinergic terminals. In young adult (2 months) rats, 64 and 36% of cholinergic...
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by d...
Yu, Liqun; Shen, Hai-Ying; Coelho, Joana E.; Araújo, Inês M.; Huang, Qing-Yuan; Day, Yuan-Ji; Rebola, Nelson; Canas, Paula M.; Rapp, Erica KirstenTo investigate whether the motor and neuroprotective effects of adenosine A2A receptor (A2AR) antagonists are mediated by distinct cell types in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease.We used the forebrain A2AR knock-out mice coupled with flow cytometric analyses and intracerebroventricular injection to determine the contribution of A2ARs in forebrain neurons and gl...
Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of...
Silva, Carla G.; Porciúncula, Lisiane O.; Canas, Paula M.; Oliveira, Catarina R.; Cunha, Rodrigo A.Since adenosine A2A receptor (A2ARs) blockade protects against noxious brain insults involving apoptosis, we directly tested if A2AR blockade prevents apoptosis induced by staurosporine (STS). Exposure of rat hippocampal neurons to STS (30 nM, 24 h) decreased neuronal viability while increasing the number apoptotic-like neurons and de-localizing mitochondria and cytochrome c immunoreactivities. This was prevent...
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