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Development of novel bilayered structures to be used as an osteochondral in vit...
Canadas, Raphael Faustino; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Proper in vitro models to evaluate the performance of relevant tissue engineered constructs are still a major demand of the field. The use of in vitro platforms in research presents obvious ethical and cost advantages over in vivo models. In vitro models can also offer important scientific advantages, as for exampl...
Novel bilayered Gellan gum/Gellan gum hydroxyapatite scaffolds for osteochondra...
Canadas, Raphael Faustino; Pereira, D. R.; Correia, Joana Silva; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.Osteoarthritis is a major cause of disability during aging. By the age of 60, close to 100% of the population will have histologic changes of degeneration in their knee cartilage (Loeser, 2000). Because of its avascular nature, cartilage has little capacity to self-regenerate. Despite the progress already achieved in osteochondral regeneration, some limitations have to be overcome. The formation of fibrocartila...
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