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Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-ind...
Silva, Ana Paula Ventura; Melo, António; Ferreira, Ana Catarina; Carvalho, M. M.; Campos, Filipa L.; Sousa, Nuno; Pêgo, José M.The extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known t...
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disea...
Carvalho, Miguel; Campos, Filipa L.; Coimbra, Bárbara Guimarães Salazar; Pêgo, José M.; Lima, Rui; Rodrigues, Ana João; Sousa, Nuno; Salgado, António J.BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic netwo...
Rodent models of Parkinson's disease : beyond the motor symptomatology
Campos, Filipa L.; Carvalho, Miguel; Cristov??o, Ana C.; Je, Goun; Baltazar, Gra??a; Salgado, Ant??nio J.; Kim, Yoon-Seong; Sousa, NunoParkinson's disease (PD) is classically characterized by motor symptoms; however, non-motor symptoms (NMS) are increasingly recognized as relevant in disease-state, given the associated alterations in mood (depression and anxiety) and cognition. Here, particularly in regards to NMS, we aimed to compare the motor, emotional and cognitive behavior of three animal models of PD that trigger dopaminergic (DAergic) d...
Neudesin is involved in anxiety behavior : structural and neurochemical correlates
Novais, Ashley da Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...
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