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Critical success factors for a total quality culture: A structural model

Research on quality based on the cultural perspective claims that, more than an implementation of tools and techniques, quality is the outcome of cultural factors, namely organisational values and practices among which leadership and employee working patterns are of paramount importance. The development of a total quality culture is a strategic issue for the achievement of stakeholder satisfaction and business ...

Peer support for people with mental illness = Suporte interpares na doença mental

HANSEN DISEASE AND PREGNANCY

Hansen disease, commonly called Leprosy, is an infectious disease caused by Mycobacterium leprae. In the past, the seriousness of the presentation of this disease associated with the inexistence of appropriate treatment, led to the stigmatization of these patients. Fortunately, the way we look now to Hansen disease has changed thanks to the existence of new antibacillary drugs. With migration phenomenon, we se...

Plombage Therapy

Contar histórias com crianças autistas

Tese de mestrado em Informática, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2013 ; O Autismo define-se como uma deficiência que afeta o neurodesenvolvimento das crianças, focando-se em três áreas principais: comunicação, interação social e imaginação. As dificuldades sentidas nestas três áreas têm como consequência um baixo nível de desempenho nos comportamentos sociais. Isto deve-...

O silêncio em Paula Rego

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Filosofia, especialidade de - Estética ; Esta dissertação constitui um conjunto de reflexões sobre o tema filosófico do silêncio no trabalho artístico de Paula Rego. Partindo inicialmente da ideia de Wittgenstein, presente no final do Tractatus, que conclui que a filosofia é silêncio, e que acaba por ser a alava...

A new anti-feedant clerodane diterpenoid from tinospora cordifolia

Phytochemical investigation of the chloroform extract of Tinospora cordifolia yielded a new clerodane diterpenoid tincordin (1) along with tinosporide (2), 8-hydroxytinosporide (3), columbin (4), 8-hydroxycolumbin (5) and 10-hydroxycolumbin (6). The structure of the new compound was elucidated comprehensively using 1D and 2D NMR methods. All major clerodane diterpenoids isolated were tested for their efficacy a...

Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a ...

Accepted author version posted online: 05 Jun 2012 ; The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described. Alkylation of isatin, 3-methyl-carbazole and one tetrahydro-gamma-carboline with propargyl bromide gave their N-propargyl derivatives in good yields. These compounds further reacted with acetylated D-glucose ...

Synthesis of glycoconjugates containing a 1,2,3-triazole unit

The preparation of several alkynyl esters, derived from amino acids, coumarins and an alkynyl derivative of acetylated D-glucose is described. Eight new glycoconjugates containing the 1,2,3-triazole unit were obtained, by a click approach from the above referred alkynyl derivatives with tetracetyl-beta-D-glucosylazide, prepared in situ from alpha-acetobromoglucose.

Synthesis of novel psoralen analogues and their in vitro antitumor activity

New tetracyclic benzofurocoumarin (benzopsoralen) analogues were synthesized and their inhibitory effect on the growth of tumor cell lines was evaluated. The human tumor cell lines used were MDA MB231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma). The in vitro antitumor activity of the new benzopsoralens was discussed in terms of structure–activity relat...