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Troponin T isoform expression is modulated during Atlantic Halibut metamorphosis
Campinho, M. A.; Silva, Nadia; Nowell, Mari A.; Llewellyn, Lynda; Sweeney, Glen E.; Power, DeborahBackground: Flatfish metamorphosis is a thyroid hormone (TH) driven process which leads to a dramatic change from a symmetrical larva to an asymmetrical juvenile. The effect of THs on muscle and in particular muscle sarcomer protein genes is largely unexplored in fish. The change in Troponin T (TnT), a pivotal protein in the assembly of skeletal muscles sarcomeres and a modulator of calcium driven muscle contra...
Regulation of troponin T expression during muscle development in sea bream Spar...
Campinho, M. A.; Sweeney, G. E.; Power, DeborahIn the sea bream Sparus auratus three stage-specific fast troponin T (fTnT) isoforms have been cloned and correspond to embryonic-, larval- and adult-specific isoforms. Characterisation, using database searches, of the putative genomic organisation of Fugu rubripes and Tetraodon nigroviridis fTnT indicates that alternative exon splicing in the 59 region of the gene generates the different isoforms. Moreover, co...
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