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mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma
Faustino, A; Couto, JP; Pópulo, H; Rocha, AS; Pardal, F; Cameselle-Teijeiro, JM; Lopes, JM; Sobrinho-Simões, M; Soares, PCONTEXT: There are several genetic and molecular evidences suggesting dysregulation of the mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia. Activation of the phosphatidylinositol-3-kinase/AKT pathway by RET/PTC and mutant RAS has already been demonstrated, but no data have been reported for the BRAF(V600E) mutation. OBJECTIVE: The aim of this study was to evaluate the activation pattern of the...
mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma
Faustino, A; Couto, JP; Pópulo, H; Rocha, AS; Pardal, F; Cameselle-Teijeiro, JM; Lopes, JM; Sobrinho-Simões, M; Soares, PCONTEXT: There are several genetic and molecular evidences suggesting dysregulation of the mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia. Activation of the phosphatidylinositol-3-kinase/AKT pathway by RET/PTC and mutant RAS has already been demonstrated, but no data have been reported for the BRAF(V600E) mutation. OBJECTIVE: The aim of this study was to evaluate the activation pattern of the...
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