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Antifungal activity of the naphthoquinone beta-lapachone against disseminated i...

The in vivo antifungal activity of the naphthoquinone beta-lapachone against disseminated infection by Cryptococcus neoformans was investigated. Swiss mice were immunosuppressed daily with dexamethasone (0.5 mg per mouse) intraperitoneally for 3 days, the procedure was repeated 4 days later, and the animals were then challenged intravenously with C. neoformans (10(6) CFU/mL) 1 week later. Seven days after infec...

Motor behavioral abnormalities and histopathological findings of Wistar rats in...

The objective of the present study was to describe motor behavioral changes in association with histopathological and hematological findings in Wistar rats inoculated intravenously with human T-cell lymphotropic virus type 1 (HTLV-1)-infected MT2 cells. Twenty-five 4-month-old male rats were inoculated with HTLV-1-infected MT2 cells and 13 control rats were inoculated with normal human lymphocytes. The behavior...

Pain in tropical spastic paraparesis: HTLV-I associated myelopathy patients

Global fire activity patterns (1996-2006) and climatic influence: an analysis u...

Vegetation fires have been acknowledged as an environmental process of global scale, which affects the chemical composition of the troposphere, and has profound ecological and climatic impacts. However, considerable uncertainty remains, especially concerning intra and inter-annual variability of fire incidence. The main goals of our globalscale study were to characterise spatial-temporal patterns of fire activi...

Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and inter...

The cytotoxic activity of amino (3a-e), aza-1-antraquinone (4a-e) lapachol derivatives against Ehrlich carcinoma and human K562 leukemia cells was investigated. Cell viability was determined using MTT assay, after 48 (Ehrlich) or 96 h (K562) of culture, and vincristine (for K562 leukemia) and quercetin (for Ehrlich carcinoma) were used as positive controls. The results showed dose-dependent growth-inhibiting ac...

Estudo comparativo do óleo essencial de Eugenia punicifolia (HBK) DC. de difere...

O óleo essencial obtido por hidrodestilação das folhas de Eugenia punicifolia, coletados a partir de duas regiões de Matas Serranas do Estado de Pernambuco (Serra Negra e Brejo da Madre de Deus), foi analisado por CG/EM. O monoterpeno oxigenado, linalol (SN: 44,0%, BMD: 61,2%), foi o componente principal do óleo de ambas amostras. Cerca de 66,2% da constituição dos voláteis da amostra proveniente de SN e 74,2% ...

Neonatal administration of citalopram delays somatic maturation in rats

We investigated the somatic maturation of neonate rats treated during the suckling period with citalopram, a selective serotonin reuptake inhibitor. Groups with 6 male neonates were randomly assigned to different treatments 24 h after birth. Each litter was suckled by one of the dams until the 21st postnatal day. Body weight, head axis and tail length were measured daily from the 1st to the 21st postnatal day. ...

Flavonóides isolados do pólen coletado pela abelha Scaptotrigona bipunctata (ca...

Pólen de abelhas é uma mistura de pólens florais coletados pelas abelhas com ampla variação na sua composição. Investigação do pólen coletado pela abelha sem ferrão Scaptotrigona bipunctata levou a quatro agliconas de flavonóides: miricetina, dihidromiricetina, quercetina e isoramnetina. As estruturas foram estabelecidas a partir de dados espectroscópicos (NMR) das substâncias naturais.