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Antioxidant phenolic esters with potential anticancer activity: solution equili...
Machado, N. F. L.; Calheiros, R.; Gaspar, A.; Garrido, J.; Borges, F.; Marques, M. P. M.The solution Raman pattern of a series of structurally related hydroxycinnamic and hydroxybenzoicesters (caffeates and gallates) with potential antioxidant/anticancer activity was studied, for different biologically significant concentrations. The spectra were assigned with the help of theoretical calculations in the light of previously reported experimental data for these compounds in the solid state. Evidence...
Antioxidant phenolic esters with potential anticancer activity: A Raman spectro...
Calheiros, R.; Machado, N. F. L.; Fiuza, S. M.; Gaspar, A.; Garrido, J.; Milhazes, N.; Borges, F.; Marques, M. P. M.A Raman study of hydroxycinnamic and hydroxybenzoic esters (caffeates, ferulates and gallates) displaying antioxidant and anticancer properties was undertaken, with particular emphasis on the analysis of the effect of the ring substituents and the nature of the ester alkyl chain on their spectroscopic features. A complete assignment of the spectra was carried out for all the compounds investigated, in the light...
Biological activity of antitumoural MGBG: the structural variable
Marques, M.; Gil, F.; Calheiros, R.; Battaglia, V.; Brunati, A.; Agostinelli, E.; Toninello, A.Abstract The present study aims at determining the structure-activity relationships (SAR’s) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activit...
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