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Regulation of AMPA receptors and synaptic plasticity
Santos, S. D.; Carvalho, A. L.; Caldeira, M. V.; Duarte, C. B.Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracell...
Role of the brain-derived neurotrophic factor at glutamatergic synapses
Carvalho, A. L.; Caldeira, M. V.; Santos, S. D.; Duarte, C. B.The neurotrophin brain-derived neurotrophic factor (BDNF) plays an important role in the activity-dependent regulation of synaptic structure and function, particularly of the glutamatergic synapses. BDNF may be released in the mature form, which activates preferentially TrkB receptors, or as proBDNF, which is coupled to the stimulation of the p75(NTR). In the mature form BDNF induces rapid effects on glutamate ...
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