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Infecção pelo vírus da hepatite B (HBV) em crianças e jovens
Barros, M. F.; Matias, S. R.; Caetano, J. A. MachadoA infecção pelo vírus da hepatite B contraída na infância é grave pela frequente evolução para cronicidade e suas consequências.Com o objectivo de melhor caracterizar a situação em doentes portugueses, estudámos um grupo de 46 crianças de menos de 15 anos comparando-o com um grupo de jovens entre 16 e 25 anos e outro de adultos, quanto a marcadores serológicos e presença de replicação viral activa através da pe...
Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 i...
Barros,M.F.; Piedade,J.; Nunes,G.; Canas-Ferreira,W.; Silva,A.P.; Champalimaud,J.L.; Machado-Caetano,J.A.To evaluate the effect of concurrent infection by HIV on HBV infection or immunity, we have studied a group of 66 HIV1+ symptomatic Caucasian patients and another of 38 African HIV2+ asymptomatic individuals, concerning their HBV status: serological markers of infection and presence of HBV-DNA in serum, the last taken as sign of hepatitis B virus active replication, were monitored. HIV+ groups were compared wit...
Immunologic aspects of HIV infection.
Caetano, J A; Serviço de Imunologia, Faculdade de Ciências Médicas, Lisboa Universidade Nova de Lisboa.Infection of Human organism by Human Immunodeficiency viruses induces, after a shorter or a longer period, a complex immune Deficiency (ID) that has been named Acquired Immune Deficiency Syndrome (AIDS). Although the designation is not correct, it has been accepted by the scientific community. AIDS includes multiple clinical situations that have in common HIV infection and an almost constant ID, that at the end...
Eradication of hepatitis B in Portugal. A challenge within reach of the Nationa...
Caetano, J A; Serviço de Imunologia da Faculdade de Ciências Médicas da Universidade Nova de Lisboa.The aim of this work is to evaluate a major epidemiological problem--human hepatitis B virus (HBV) infection--in the world and in Portugal--reinforcing WHO's view that it is a worldwide health problem. Portugal is considered a risk area for HBV infection, with 30% of the population having had contact with the virus and 1 to 5% of chronic carriers (100 to 150,000 persons). Deficient information, education and sa...
Profile of the resistance to macrolides and imidazoles of Helicobacter pylori i...
Rosário, M; Serviço de Gastroenterologia, Instituto Clinico e Imunológico de Lisboa.; Caetano, J M; Pessanha, M A; Marote, G; da Silva, J AWe studied the sensitivity of H. pylori to clarithromycin and metronidazole, as well as the sensitivity and specificity of H. pylori culture, urease test and histology on a sample of 166 Portuguese patients. We observed a prevalence of 5.8% resistance to clarithromycin and 60% resistance to metronidazole. The sensitivity and specificity for the diagnostic tests were: culture 98% and 100%, urease test 98% and 91...
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