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Redox interactions of nitric oxide with dopamine and its derivatives
Antunes, Fernando; Nunes, Carla; Laranjinha, João; Cadenas, EnriqueNitric oxide (NO) is a ubiquitous diffusible messenger in the central nervous system. NO and derived nitrogen species may interact with catecholamines, thus, modifying not only its regulatory actions but also producing oxidants and free radicals that are likely to trigger toxic pathways in the nervous system. Oxidative pathways and chain oxidation reactions triggered by catecholamines may be broken by ascorbate...
Concentration Dynamics of Nitric Oxide in Rat Hippocampal Slices
Ledo, Ana; Barbosa, Rui M.; Cadenas, Enrique; Gerhardt, Greg; Laranjinha, JoãoNitric oxide () production in response to stimulation of the NMDA glutamate receptor is implicated not only in the synaptic plasticity in hippocampus but may also participate in excitotoxic cell death. Using -selective microssensors inserted into the diffusional field of in acute hippocampal slices, we describe the concentration dynamics evoked by NMDA receptor activation and report profound differences along...
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by ...
Ledo, Ana; Barbosa, Rui M.; Gerhardt, Greg A.; Cadenas, Enrique; Laranjinha, JoãoNitric oxide (*NO) production in response to stimulation of the NMDA glutamate receptor is implicated not only in the synaptic plasticity in hippocampus but may also participate in excitotoxic cell death. Using *NO-selective microssensors inserted into the diffusional field of *NO in acute hippocampal slices, we describe the *NO concentration dynamics evoked by NMDA receptor activation and report profound diffe...
Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase
Laranjinha, João; Cadenas, EnriqueThis study aimed to characterize the redox interaction between 3,4-dihydroxyphenylacetic acid (DOPAC) and nitric oxide (·NO), and to assess the reductive and oxidative decay pathways of the DOPAC semiquinone originating from this interaction. The reaction between DOPAC and ·NO led to the formation of the DOPAC semiquinone radical, detected by electron paramagnetic resonance (EPR) and stabilized by Mg2+, and the...
Redox Cycles of Caffeic Acid, alpha-Tocopherol, and Ascorbate: Implications for...
Laranjinha, João; Cadenas, EnriqueThis study addresses the dynamic interactions among alpha-tocopherol, caffeic acid, and ascorbate in terms of a sequence of redox cycles aimed at accomplishing optimal synergistic antioxidant protection. Several experimental models were designed to examine these interactions: UV irradiation of alpha-tocopherol-containing sodium dodecyl sulfate micelles, one-electron oxidations catalyzed by the hypervalent state...
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